Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

458 questions · 466 findings · 48 reviews · Schizophrenia

No studies found 87 · 18.7%GRADE not reported 82 · 17.6%Very low 153 · 32.8%Low 111 · 23.8%Moderate 19 · 4.1%High 14 · 3%

Adjunctive lithium + antipsychotics vs placebo/no adjunctive treatment + antipsychotics

Clinically significant response on positive symptoms at least 50% MS improvement · schizophrenia

Adjunctive lithium + antipsychotics showed no clear difference in clinically significant response on positive symptoms at least 50% MS… compared with placebo/no adjunctive treatment + antipsychotics (low certainty).

1 finding from 1 review

Lithium as sole treatment vs placebo

Acceptability ‐ total dropouts · schizophrenia

Lithium as sole treatment showed no clear difference in acceptability of treatment leaving early due to any reason compared with placebo (low certainty).

1 finding from 1 review

Lithium as sole treatment vs placebo

> 50% reduction in depressive symptoms · schizophrenia

Lithium as sole treatment showed no clear difference in clinically significant response on depressive symptoms at least 50%… compared with placebo (low certainty).

1 finding from 1 review

Lithium as sole treatment vs placebo

Clinically significant response on manic symptoms at least 50% Bech‐Rafaelsen improvement · schizophrenia

Lithium as sole treatment showed no clear difference in clinically significant response on manic symptoms at least 50%… compared with placebo (low certainty).

1 finding from 1 review

Lithium as sole treatment vs placebo

Clinically significant response on positive symptoms at least 50% MS improvement · schizophrenia

Lithium as sole treatment showed no clear difference in clinically significant response on positive symptoms at least 50% MS… compared with placebo (low certainty).

1 finding from 1 review

Lithium as sole treatment vs placebo

Kidney dysfunction outcome not available in any study · schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Lithium as sole treatment vs placebo

Thyroid dysfunction outcome not available in any study · schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Pyridoxal 5 phosphate (vitamin B6) vs placebo

Clinical efficacy ‐ improvement (> 40%) in ESRS scores from baseline ESRS1 · patients with antipsychotic‐induced tardive dyskinesia

Pyridoxal 5 phosphate (vitamin B6) may leads to higher clinical efficacy ‐ improvement (> 40%) in ESRS scores from baseline… compared with placebo (low certainty).

1 finding from 1 review

Pyridoxal 5 phosphate (vitamin B6) vs placebo

Global: Other adverse effects than tardive dyskinesia Self‐report by participants · patients with antipsychotic‐induced tardive dyskinesia

Pyridoxal 5 phosphate (vitamin B6) showed no clear difference in global: Other adverse effects than tardive dyskinesia Self‐report by… compared with placebo (low certainty).

1 finding from 1 review

Pyridoxal 5 phosphate (vitamin B6) vs placebo

Tardive dyskinesia: Deterioration of symptoms · patients with antipsychotic‐induced tardive dyskinesia

Pyridoxal 5 phosphate (vitamin B6) showed no clear difference in tardive dyskinesia: Deterioration in tardive dyskinesia symptoms ESRS1 compared with placebo (low certainty).

1 finding from 1 review

Adjunctive carbamazepine + antipsychotics vs placebo/no adjunctive treatment + antipsychotics

Leaving the study early · patients with schizophrenia

It is very uncertain whether adjunctive carbamazepine + antipsychotics changes acceptability of treatment Leaving the study early due to any reason compared with placebo/no adjunctive treatment + antipsychotics (very low certainty).

1 finding from 1 review

Adjunctive carbamazepine + antipsychotics vs placebo/no adjunctive treatment + antipsychotics

Mental state: No clinically important improvement · patients with schizophrenia

Adjunctive carbamazepine + antipsychotics showed no clear difference in no clinically important change in general mental state Scale used:… compared with placebo/no adjunctive treatment + antipsychotics (low certainty).

1 finding from 1 review