Cochrane · systematic review · CD001258
Carbamazepine for schizophrenia
Leucht, S, Helfer, B, Dold, M, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
SchizophreniaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 16.7%Very low 1 · 16.7%Low 3 · 50%Moderate 1 · 16.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Adjunctive carbamazepine + antipsychotics compared with placebo/no adjunctive treatment + antipsychotics for schizophrenia
Population: People with schizophrenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Acceptability of treatment Leaving the study early due to any reason Adjunctive carbamazepine + antipsychotics vs placebo/no adjunctive treatment + antipsychotics | RR 0.47 [0.16, 1.35] | 8 studies · 182 participants | Very low Downgraded: risk of bias, inconsistency, indirectness |
No clinically important change in general mental state Scale used: less than 50% BPRS reduction Adjunctive carbamazepine + antipsychotics vs placebo/no adjunctive treatment + antipsychotics | RR 0.86 [0.67, 1.12] | 6 studies · 147 participants | Low Downgraded: risk of bias, imprecision |
Average endpoint general mental state score Scale used: Average BPRS endpoint score. Scale from: 0 to 108. Adjunctive carbamazepine + antipsychotics vs placebo/no adjunctive treatment + antipsychotics | no estimate extracted | 3 studies · 79 participants | Low Downgraded: imprecision, inconsistency |
Average endpoint positive symptom score Scale used: Mean PANSS positive subscore at endpoint. Scale from: 7 to 49. Adjunctive carbamazepine + antipsychotics vs placebo/no adjunctive treatment + antipsychotics | no estimate extracted | 1 study · 18 participants | Moderate Downgraded: imprecision |
Average endpoint depressive symptom score Scale used: Hamilton scale at endpoint. Scale from: 0 to 54. Adjunctive carbamazepine + antipsychotics vs placebo/no adjunctive treatment + antipsychotics | no estimate extracted | 1 study · 26 participants | Low Downgraded: imprecision |
Aggression Adjunctive carbamazepine + antipsychotics vs placebo/no adjunctive treatment + antipsychotics | no estimate extracted | 0 studies · 0 participants | Ungraded |