Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,773 questions · 1,817 findings · 212 reviews · Headline outcomes only

No studies found 383 · 21.1%GRADE not reported 192 · 10.6%Very low 472 · 26%Low 444 · 24.4%Moderate 228 · 12.5%High 98 · 5.4%

Larger atraumatic needles vs atraumatic needles

Paraesthesia · patients undergoing lumbar punctures with atraumatic needles (Whitacre, Atraucan, Sprotte, Cappe‐Deutsh, Pajunk, Gertie Marx, Durasafe,…

Larger atraumatic needles probably leads to lower adverse events: paraesthesia compared with smaller atraumatic needles (moderate certainty).

1 finding from 1 review

Multinutrient supplements (oral) vs control

Participants with complications (e.g. pressure sore, chest infection) at end of study · Older people undergoing hip fracture aftercare

Multinutrient supplements (oral) may leads to lower participants with complications (e.g. pressure sore, chest… compared with control (low certainty).

1 finding from 1 review

Double vs single‐injection technique

Primary anaesthesia failure (incomplete sensory block) · Adult patients undergoing hand, wrist or forearm surgery

Double leads to lower primary anaesthesia failure (incomplete sensory block) compared with single‐injection technique (high certainty).

1 finding from 1 review

RISPERIDONE DEPOT vs ARIPIPRAZOLE

Adverse events: General ‐ serious Unclear how these events were reported · patients with schizophrenia

It is very uncertain whether RISPERIDONE DEPOT changes adverse events: General ‐ serious Unclear how these events were… compared with ORAL ARIPIPRAZOLE (very low certainty).

1 finding from 1 review

Intervention not reported

Pain Acroparaesthesia and Fabry crises · Anderson‐Fabry disease

The review found no eligible studies for this question.

1 finding from 1 review