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What do systematic reviews say?

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Evidence found and GRADE certainty

567 questions · 573 findings · 37 reviews · Headline outcomes only

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No studies found 89 · 15.5%GRADE not reported 156 · 27.2%Very low 140 · 24.4%Low 127 · 22.2%Moderate 47 · 8.2%High 14 · 2.4%

Cuffed vs uncuffed tubes

Postextubation stridor (defined as any inspiratory sound or persistent barking, or presence of sternal or intercostal retractions postextubation) · Children up to eight years undergoing general anaesthesia

It is very uncertain whether cuffed changes postextubation stridor (defined as any inspiratory sound or… compared with uncuffed tubes (very low certainty).

1 finding from 1 review

Cuffed vs uncuffed tubes

Need for ETT exchange (defined as more than one attempt to arrive at the final endotracheal tube size) · Children up to eight years undergoing general anaesthesia

It is very uncertain whether cuffed changes need for ETT exchange (defined as more than one attempt to arrive at… compared with uncuffed tubes (very low certainty).

1 finding from 1 review

Cuffed vs uncuffed tubes

Need for tracheal re‐intubation for postoperative stridor (defined as the need to re‐intubate to assure oxygenation to deal with postextubation stridor) · Children up to eight years undergoing general anaesthesia

It is very uncertain whether cuffed changes need for tracheal re‐intubation for postoperative stridor (defined… compared with uncuffed tubes (very low certainty).

1 finding from 1 review

Cuffed vs uncuffed tubes

Need for epinephrine to treat stridor (defined as the need to use epinephrine to treat postextubation stridor) · Children up to eight years undergoing general anaesthesia

It is very uncertain whether cuffed changes need for epinephrine to treat stridor (defined as the need to use… compared with uncuffed tubes (very low certainty).

1 finding from 1 review

Cuffed vs uncuffed tubes

Need for intensive care unit (ICU) admission to treat post extubation stridor (as defined by the trial authors) · Children up to eight years undergoing general anaesthesia

It is very uncertain whether cuffed changes need for intensive care unit (ICU) admission to treat post… compared with uncuffed tubes (very low certainty).

1 finding from 1 review

Cuffed vs uncuffed tubes

Need for corticosteroid to treat stridor (defined as the need to use corticosteroid to treat postextubation stridor) · Children up to eight years undergoing general anaesthesia

It is very uncertain whether cuffed changes need for corticosteroid to treat stridor (defined as the need to use… compared with uncuffed tubes (very low certainty).

1 finding from 1 review