Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

395 questions · 404 findings · 37 reviews · Headline outcomes only

No studies found 83 · 20.5%GRADE not reported 41 · 10.1%Very low 127 · 31.4%Low 115 · 28.5%Moderate 38 · 9.4%High 0 · 0%

Therapist‐supported ICBT vs face‐to‐face CBT

Clinically important improvement in anxiety at post‐treatment Indexed by a standardized interview or clinically accepted measure cut‐off score1 · adults with anxiety disorders

Therapist‐supported ICBT showed no clear difference in clinically important improvement in anxiety at post‐treatment… compared with face‐to‐face CBT (low certainty).

1 finding from 1 review

CBT vs WAIT LIST

Remission of anxiety diagnoses (ITT analysis) i.e. no longer meeting criteria for DSM or ICD anxiety diagnosis at the end of the trial. · children and adolescents with anxiety disorders

CBT probably leads to higher remission of anxiety diagnoses (ITT analysis) i.e. no longer meeting… compared with wait‐list (moderate certainty).

1 finding from 1 review

CBT vs active control

Remission of anxiety diagnoses (ITT analysis) i.e. no longer meeting criteria for DSM or ICD anxiety diagnosis at the end of the trial. · children and adolescents with anxiety disorders

CBT showed no clear difference in remission of anxiety diagnoses (ITT) analysis i.e. no longer meeting… compared with active controls (moderate certainty).

1 finding from 1 review

CBT vs treatment

Remission of anxiety diagnoses (ITT analysis) i.e. no longer meeting criteria for DSM or ICD anxiety diagnosis at the end of the trial. · children and adolescents with anxiety disorders

CBT showed no clear difference in remission of anxiety diagnoses (ITT analysis) i.e. no longer meeting… compared with treatment (moderate certainty).

1 finding from 1 review