Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,072 questions · 4,237 findings · 447 reviews · Headline outcomes only

No studies found 946 · 22.3%GRADE not reported 257 · 6.1%Very low 1,121 · 26.5%Low 1,207 · 28.5%Moderate 568 · 13.4%High 138 · 3.3%

Biological graft vs native tissue repair

Postoperative complications (including wound infection) (16‐24 months) · women with posterior vaginal wall prolapse

Biological graft probably leads to higher postoperative complications (including wound infection) (16‐24 months) compared with native tissue repair (moderate certainty).

1 finding from 1 review

Transanal repair vs transvaginal repair

Recurrent posterior vaginal wall prolapse (objective failure) (12‐25 months) · women with posterior vaginal wall prolapse

Transanal repair probably leads to higher recurrent posterior vaginal wall prolapse (objective failure) (12‐25… compared with transvaginal repair (moderate certainty).

1 finding from 1 review

GnRHa treatment vs placebo or no pretreatment

Intraoperative blood loss (mL) · women with uterine fibroids
3 findings from 1 review

GnRHa treatment vs placebo or no pretreatment

Blood transfusion · women with uterine fibroids

GnRHa treatment showed no clear difference in blood transfusions compared with no pretreatment or placebo before myomectomy (operative and… (low certainty).

3 findings from 1 review

GnRHa treatment vs placebo or no pretreatment

Overall postoperative morbidity · women with uterine fibroids

GnRHa treatment showed no clear difference in postoperative morbidity compared with no pretreatment or placebo before myomectomy (operative and… (low certainty).

3 findings from 1 review

SPRM vs placebo

Preoperative bleeding: (PBAC < 75) ulipristal acetate 5 mg · women with uterine fibroids

SPRM may leads to higher preoperative bleeding: (PBAC < 75) ulipristal acetate 5 mg compared with placebo (low certainty).

1 finding from 1 review

SPRM vs placebo

Preoperative bleeding: Reduction in bleeding to PBAC < 75 ulipristal acetate 10 mg · women with uterine fibroids

SPRM may leads to higher preoperative bleeding: Reduction in menstrual bleeding (PBAC < 75)… compared with placebo (low certainty).

1 finding from 1 review