Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,771 questions · 10,185 findings · 893 reviews

No studies found 2,109 · 20.7%GRADE not reported 1,125 · 11%Very low 2,279 · 22.4%Low 2,514 · 24.7%Moderate 1,709 · 16.8%High 449 · 4.4%

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Brivaracetam vs placebo

50% or greater reduction in seizure frequency · people with drug‐resistant focal epilepsy

Brivaracetam probably leads to higher 50% or greater reduction in seizure frequency (responder rate) compared with placebo (moderate certainty).

1 finding from 1 review

Brivaracetam vs placebo

Withdrawals due to adverse events · people with drug‐resistant focal epilepsy

Brivaracetam may leads to higher proportion of participants who experienced adverse events leading to… compared with placebo (low certainty).

1 finding from 1 review

Brivaracetam vs placebo

Adverse events as N of participants with at least one adverse event objective · people with drug‐resistant focal epilepsy

Brivaracetam showed no clear difference in proportion of participants who experienced any adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Adjunctive Coriolus versicolor vs no adjunctive treatment

Withdrawals due to adverse events · adults (aged 18+) with colorectal cancer

It is very uncertain whether adjunctive Coriolus versicolor changes withdrawal from treatment due to adverse events ‐ compared with no adjunctive treatment (very low certainty).

1 finding from 1 review

Adjunctive Coriolus versicolor vs no adjunctive treatment

Adverse events: Oral cavity disorders (includes oral dryness and mucositis)‐ · adults (aged 18+) with colorectal cancer

It is very uncertain whether adjunctive Coriolus versicolor changes adverse events: Oral cavity disorders (includes oral dryness and… compared with no adjunctive treatment (very low certainty).

1 finding from 1 review

Adjunctive Coriolus versicolor vs no adjunctive treatment

Adverse events: nausea · adults (aged 18+) with colorectal cancer

It is very uncertain whether adjunctive Coriolus versicolor changes adverse events: Nausea ‐ compared with no adjunctive treatment (very low certainty).

1 finding from 1 review

Adjunctive Coriolus versicolor vs no adjunctive treatment

Diarrhoea · adults (aged 18+) with colorectal cancer

It is very uncertain whether adjunctive Coriolus versicolor changes adverse events: Diarrhoea ‐ compared with no adjunctive treatment (very low certainty).

1 finding from 1 review

Adjunctive Coriolus versicolor vs no adjunctive treatment

Adverse events: Neutrophils decreased ‐ · adults (aged 18+) with colorectal cancer

It is very uncertain whether adjunctive Coriolus versicolor changes adverse events: Neutrophils decreased ‐ compared with no adjunctive treatment (very low certainty).

1 finding from 1 review

Adjunctive Coriolus versicolor vs no adjunctive treatment

Adverse effect: fatigue · adults (aged 18+) with colorectal cancer

It is very uncertain whether adjunctive Coriolus versicolor changes adverse events: Fatigue ‐ compared with no adjunctive treatment (very low certainty).

1 finding from 1 review