Antioxidants vs placebo
Reduction of TTM symptom severityMassachusetts General Hospital Hair‐Pulling Scale (MGH‐HPS) · adults with trichotillomania
1 finding from 1 review
- no estimate extracted1 study · 27 participantsLow
Findings
What do systematic reviews say?
4,703 questions · 15,007 findings · 1,416 reviews
No studies found 2,881 · 19.2%GRADE not reported 1,551 · 10.3%Very low 3,111 · 20.7%Low 3,881 · 25.9%Moderate 2,669 · 17.8%High 914 · 6.1%
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Opioid antagonists vs placebo
Reduction of TTM symptom severityMassachusetts General Hospital Hair‐Pulling Scale (MGH‐HPS) · adults with trichotillomania
1 finding from 1 review
- no estimate extracted1 study · 51 participantsLow
Opioid antagonists vs placebo
Dropouts due to adverse events · adults with trichotillomania
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Selective serotonin reuptake inhibitors vs placebo
Treatment response · adults with trichotillomania
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Selective serotonin reuptake inhibitors vs placebo
Reduction of TTM symptom severityMassachusetts General Hospital Hair‐Pulling Scale (MGH‐HPS) · adults with trichotillomania
1 finding from 1 review
- no estimate extracted1 study · 31 participantsVery low
Selective serotonin reuptake inhibitors vs placebo
Dropouts due to adverse events · adults with trichotillomania
SSRIs showed no clear difference in tolerability of treatment ‐ dropouts due to adverse eventseDropout… compared with placebo (low certainty).
1 finding from 1 review
- RR 3 [0.33, 27.62]2 studies · 78 participantsLow
TCAs with predominantly SRI actions vs placebo
Clinical Global Impressions scale change item (CGI‐I): no. of responders (long term) Post‐treatment: 1‐4 months · adults with trichotillomania
It is very uncertain whether TCAs with predominantly SRI actions changes treatment responseaClinical Global Impressions ‐ Improvement Scale… compared with placebo (very low certainty).
1 finding from 1 review
- RR 5.73 [0.36, 90.83]1 study · 16 participantsVery low
TCAs with predominantly SRI actions vs placebo
Reduction of TTM symptom severityNIMH Trichotillomania Severity Scale (NIMH‐TSS) · adults with trichotillomania
1 finding from 1 review
- no estimate extracted1 study · 16 participantsVery low
TCAs with predominantly SRI actions vs placebo
Dropouts due to adverse events · adults with trichotillomania
It is very uncertain whether TCAs with predominantly SRI actions changes tolerability of treatment ‐ dropouts due to adverse eventsdDropout… compared with placebo (very low certainty).
1 finding from 1 review
- RR 4.45 [0.27, 73.81]1 study · 16 participantsVery low
Antioxidants vs placebo
Withdrawals due to adverse events · adults with trichotillomania
1 finding from 1 review
- no estimate extracted1 study · 18 participantsLow
Antioxidants vs placebo
Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · children with trichotillomania
Antioxidants showed no clear difference in treatment responseaClinical Global Impressions ‐ Improvement Scale… compared with placebo (low certainty).
1 finding from 1 review
- RR 2 [0.28, 14.2]1 study · 8 participantsLow
Antioxidants vs placebo
Reduction of TTM symptom severityMassachusetts General Hospital Hair‐Pulling Scale (MGH‐HPS) · children with trichotillomania
1 finding from 1 review
- no estimate extracted1 study · 6 participantsLow
Antioxidants vs placebo
Withdrawals due to adverse events · children with trichotillomania
1 finding from 1 review
- no estimate extracted1 study · 6 participantsLow
Antipsychotics vs placebo
Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · adults with trichotillomania
Antipsychotics may leads to higher treatment responseaClinical Global Impressions ‐ Improvement Scale… compared with placebo (low certainty).
1 finding from 1 review
- RR 5.08 [1.4, 18.37]1 study · 25 participantsLow
Antipsychotics vs placebo
Reduction of TTM symptom severityMassachusetts General Hospital Hair‐Pulling Scale (MGH‐HPS) · adults with trichotillomania
1 finding from 1 review
- no estimate extracted1 study · 25 participantsLow
Antipsychotics vs placebo
Withdrawals due to adverse events · adults with trichotillomania
1 finding from 1 review
- no estimate extracted1 study · 25 participantsLow
Pentoxifylline vs placebo
Live birth rate · women with endometriosis
The review found no eligible studies for this question.
1 finding from 1 review
- Pentoxifylline for the treatment of endometriosis‐associated pain and infertility 2021 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Pentoxifylline vs placebo
Overall pain · women with endometriosis
The review found no eligible studies for this question.
1 finding from 1 review
- Pentoxifylline for the treatment of endometriosis‐associated pain and infertility 2021 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Pentoxifylline vs placebo
Clinical pregnancy rate · women with endometriosis
It is very uncertain whether pentoxifylline changes clinical pregnancy rate compared with placebo (very low certainty).
1 finding from 1 review
- Pentoxifylline for the treatment of endometriosis‐associated pain and infertility 2021 · Cochrane Headline outcomes onlyRR 1.38 [0.91, 2.1]3 studies · 285 participantsVery low
Pentoxifylline vs placebo
Miscarriage · women with endometriosis
It is very uncertain whether pentoxifylline changes miscarriage rate compared with placebo (very low certainty).
1 finding from 1 review
- Pentoxifylline for the treatment of endometriosis‐associated pain and infertility 2021 · Cochrane Headline outcomes onlyPeto OR 1.99 [0.2, 19.37]2 studies · 164 participantsVery low