Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,072 questions · 4,237 findings · 447 reviews · Headline outcomes only

No studies found 946 · 22.3%GRADE not reported 257 · 6.1%Very low 1,121 · 26.5%Low 1,207 · 28.5%Moderate 568 · 13.4%High 138 · 3.3%

Intervention not reported

Proportion free from seizures at 1 year · adults and children with drug‐resistant epilepsy suitable for surgical intervention

The intervention may leads to higher proportion free from seizures at 1 year (low certainty).

1 finding from 1 review
  • Surgery for epilepsy 2019 · Cochrane Headline outcomes only
    RR 9.78 [4.73, 20.21]
    2 studies · 196 participants
    Low

Intervention not reported

Proportion free from all seizures (including auras) at 1 year · adults and children with drug‐resistant epilepsy suitable for surgical intervention

It is very uncertain whether the intervention changes proportion free from all seizures (including auras) at 1 year (very low certainty).

1 finding from 1 review
  • Surgery for epilepsy 2019 · Cochrane Headline outcomes only
    RR 15 [2.08, 108.23]
    1 study · 80 participants
    Very low

Intervention not reported

Proportion free from seizures (Engel Class 1 or 1A) at 1 year and at 5 years · adults and children with drug‐resistant epilepsy suitable for surgical intervention
1 finding from 1 review
  • Surgery for epilepsy 2019 · Cochrane Headline outcomes only
    no estimate extracted
    1 study · 43 participants
    Low

Intervention not reported

P roportion with remission of seizures (at least Engel Class IB) between 25 and 36 months · adults and children with drug‐resistant epilepsy suitable for surgical intervention

The intervention may leads to lower P roportion with remission of seizures (at least Engel Class IB)… (low certainty).

1 finding from 1 review
  • Surgery for epilepsy 2019 · Cochrane Headline outcomes only
    RR 0.66 [0.45, 0.99]
    1 study · 58 participants
    Low

Intervention not reported

Proportion free from seizures (Engel Class 1) at 1 year · adults and children with drug‐resistant epilepsy suitable for surgical intervention

The intervention showed no clear difference in proportion free from seizures (Engel Class 1) at 1 year (low certainty).

1 finding from 1 review
  • Surgery for epilepsy 2019 · Cochrane Headline outcomes only
    RR 1.14 [0.76, 1.7]
    1 study · 43 participants
    Low

Intervention not reported

Proportion free from seizures (Engel Class 1) at 2 years · adults and children with drug‐resistant epilepsy suitable for surgical intervention

The intervention showed no clear difference in proportion free from seizures (Engel Class 1) at 2 years (moderate certainty).

1 finding from 1 review
  • Surgery for epilepsy 2019 · Cochrane Headline outcomes only
    RR 1.22 [0.85, 1.76]
    1 study · 60 participants
    Moderate

Intervention not reported

Proportion free from all seizures (including auras, ILAE 1a) at 1 year · adults and children with drug‐resistant epilepsy suitable for surgical intervention

The intervention showed no clear difference in proportion free from all seizures (including auras, ILAE 1a) at 1 year (low certainty).

1 finding from 1 review
  • Surgery for epilepsy 2019 · Cochrane Headline outcomes only
    RR 0.92 [0.59, 1.46]
    1 study · 47 participants
    Low

Intervention not reported

Proportion free from all seizures (including auras) at 1 year · adults and children with drug‐resistant epilepsy suitable for surgical intervention

The intervention may leads to higher proportion free from all seizures (including auras) at 1 year (low certainty).

1 finding from 1 review
  • Surgery for epilepsy 2019 · Cochrane Headline outcomes only
    RR 1.82 [1.12, 2.93]
    1 study · 70 participants
    Low

Intraoperative neuromonitoring vs visual nerve identification only during thyroidectomy

Adverse events other than RILN palsy (participants) Definition: transient hypoparathyroidism

It is very uncertain whether intraoperative neuromonitoring changes adverse events other than RILN palsy (participants) Definition:… compared with visual nerve identification only during thyroidectomy (very low certainty).

1 finding from 1 review

IStent in combination with phacoemulsification vs phacoemulsification alone

Proportion of participants who were drop‐free · open‐angle glaucoma

It is very uncertain whether IStent in combination with phacoemulsification changes proportion of participants who were drop‐free compared with phacoemulsification alone (very low certainty).

1 finding from 1 review