Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,315 questions · 23,557 findings · 2,311 reviews

No studies found 4,183 · 17.8%GRADE not reported 3,930 · 16.7%Very low 5,371 · 22.8%Low 5,787 · 24.6%Moderate 3,320 · 14.1%High 966 · 4.1%

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Live zoster vaccine vs placebo

Systemic adverse events at · healthy older adults aged ≥ 60 years

Live zoster vaccine showed no clear difference in participants with adverse events ‐ systemic adverse eventsClinical… compared with placebo (moderate certainty).

1 finding from 1 review

Live zoster vaccine vs placebo

Participants with adverse events ‐ injection site adverse events Clinical criteria · healthy older adults aged ≥ 60 years

Live zoster vaccine probably leads to higher participants with adverse events ‐ injection site adverse… compared with placebo (moderate certainty).

1 finding from 1 review

Live zoster vaccine vs placebo

Dropouts Clinical or laboratory criteria · healthy older adults aged ≥ 60 years

Live zoster vaccine showed no clear difference in dropoutsClinical or laboratory criteria compared with placebo (moderate certainty).

1 finding from 1 review

Recombinant zoster vaccine vs placebo

Cumulative incidence of herpes zoster at least 3.2 years · healthy older adults aged ≥ 60 years

Recombinant zoster vaccine probably leads to lower cumulative incidence of herpes zoster at least 3.2 years compared with placebo (moderate certainty).

1 finding from 1 review

Recombinant zoster vaccine vs placebo

Participants with adverse events ‐ death Clinical criteria · healthy older adults aged ≥ 60 years

Recombinant zoster vaccine showed no clear difference in participants with adverse events ‐ deathClinical criteria compared with placebo (moderate certainty).

1 finding from 1 review

Zinc vs no zinc supplementation

Mortality due to all‐cause diarrhea · otherwise healthy children aged 6 months to 12 years of age

Zinc supplementation showed no clear difference in mortality due to all‐cause diarrhea compared with no zinc supplementation (moderate certainty).

1 finding from 1 review

Condiments/seasonings fortified with iron vs unfortified condiments/seasonings

Anaemia · population aged 2 years and above (Ballot 1989a (C) ‐ > 10 years, Chen 2005 (C) ‐ >3 years; Huo 2002 ‐ 11‐17 years, Longfils 2008‐ 6‐21…

It is very uncertain whether condiments/seasonings fortified with iron changes anaemia (defined as haemoglobin below WHO cut‐off for age and… compared with unfortified condiments/seasonings (very low certainty).

1 finding from 1 review

Condiments/seasonings fortified with iron plus other micronutrients vs condiments/seasonings fortified with other micronutrients except iron

Iron deficiency (as defined by study authors, based on a biomarker of iron status) · population aged 2 years and above (Andersson 2008 ‐ 5‐18 years, Asibey‐Berko 2007 ~ 3 years, Chen Ke 2008 ‐ 2‐6 years, Haas 2014 ‐ women…

Condiments/seasonings fortified with iron plus other micronutrients may leads to lower iron deficiency (as defined by the trialists based on a biomarker of… compared with condiments/seasonings fortified with other micronutrients except iron (low certainty).

1 finding from 1 review

Condiments/seasonings fortified with iron plus other micronutrients vs condiments/seasonings fortified with other micronutrients except iron

Ferritin (µg/L) · population aged 2 years and above (Andersson 2008 ‐ 5‐18 years, Asibey‐Berko 2007 ~ 3 years, Chen Ke 2008 ‐ 2‐6 years, Haas 2014 ‐ women…
1 finding from 1 review

Condiments/seasonings fortified with iron plus other micronutrients vs condiments/seasonings fortified with other micronutrients except iron

Transferrin saturation · population aged 2 years and above (Andersson 2008 ‐ 5‐18 years, Asibey‐Berko 2007 ~ 3 years, Chen Ke 2008 ‐ 2‐6 years, Haas 2014 ‐ women…
1 finding from 1 review

Condiments/seasonings fortified with iron plus other micronutrients vs condiments/seasonings fortified with other micronutrients except iron

Total iron binding capacity · population aged 2 years and above (Andersson 2008 ‐ 5‐18 years, Asibey‐Berko 2007 ~ 3 years, Chen Ke 2008 ‐ 2‐6 years, Haas 2014 ‐ women…
1 finding from 1 review

Condiments/seasonings fortified with iron plus other micronutrients vs condiments/seasonings fortified with other micronutrients except iron

Adverse effects · population aged 2 years and above (Andersson 2008 ‐ 5‐18 years, Asibey‐Berko 2007 ~ 3 years, Chen Ke 2008 ‐ 2‐6 years, Haas 2014 ‐ women…
1 finding from 1 review