Question · asked by 1 review

Live zoster vaccine vs placebo: Participants with adverse events ‐ injection site adverse events Clinical criteria

Live zoster vaccine probably leads to higher participants with adverse events ‐ injection site adverse… compared with placebo (moderate certainty).

What each review found

Include earlier review versions
FindingEffectStudiesGRADE certainty
Live zoster vaccine vs placebo
Participants with adverse events ‐ injection site adverse eventsClinical criteria · healthy older adults aged ≥ 60 years
Live zoster vaccine probably leads to higher participants with adverse events ‐ injection site adverse… compared with placebo (moderate certainty).
Vaccines for preventing herpes zoster in older adults (2023) · Cochrane Headline outcomes only
RR 3.73 [1.93, 7.21]4 studies · 7040 participantsModerate

Findings are shown side by side, never pooled across reviews.

The reviews

ReviewSearched up toIncluded studiesAMSTAR 2
Vaccines for preventing herpes zoster in older adults
2023 · Cochrane Headline outcomes only
Not reportedlist not extracted yetNot assessed

Studies behind the findings

None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.

How reviews are matched to this question

Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.