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What do systematic reviews say?

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Evidence found and GRADE certainty

766 questions · 806 findings · 76 reviews · ENT

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No studies found 293 · 36.4%GRADE not reported 6 · 0.7%Very low 244 · 30.3%Low 170 · 21.1%Moderate 85 · 10.5%High 8 · 1%

CBT vs no treatment or waiting list

Serious adverse effects at end of treatment · adults with tinnitus

CBT showed no clear difference in serious adverse effects at end of treatment compared with no intervention/waiting list control (moderate certainty).

1 finding from 1 review

Intervention not reported

Health‐related quality of life · CSOM, recurrence of CSOM or suppuration following mastoidectomy or tympanoplasty

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Ear pain (otalgia) or discomfort or local irritation · CSOM, recurrence of CSOM or suppuration following mastoidectomy or tympanoplasty

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Hearing · CSOM, recurrence of CSOM or suppuration following mastoidectomy or tympanoplasty

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Serious complications · CSOM, recurrence of CSOM or suppuration following mastoidectomy or tympanoplasty

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Suspected ototoxicity · CSOM, recurrence of CSOM or suppuration following mastoidectomy or tympanoplasty
1 finding from 1 review

Quinolone vs aminoglycosides

Resolution of ear discharge ‐ measured at 1 to 2 weeks · people (of any age) with CSOM

It is very uncertain whether quinolones changes resolution of ear discharge ‐ measured at 1 to 2 weeks compared with aminoglycosides (very low certainty).

1 finding from 1 review