Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

538 questions · 561 findings · 59 reviews

No studies found 184 · 32.8%GRADE not reported 185 · 33%Very low 86 · 15.3%Low 58 · 10.3%Moderate 38 · 6.8%High 10 · 1.8%

Autogenous bone graft augmentation at the immediate implant site vs No augmentation

Implant failure · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Autogenous bone graft augmentation at the immediate implant site led to lower implant failure compared with no augmentation; GRADE not reported.

1 finding from 1 review

Bio-Oss (anorganic bovine bone) vs Bovine-derived xenograft (Bio-Oss) plus resorbable barrier

Aesthetics · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Bio-Oss (anorganic bovine bone) led to lower poor aesthetics measured by dentist (after restoration) compared with bio-Oss + resorbable barrier; GRADE not reported.

1 finding from 1 review

Resorbable barrier (guided bone regeneration) vs Non-resorbable barrier (guided bone regeneration)

Major complications at the implant/donor site · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Resorbable barrier (guided bone regeneration) led to lower major complications at the implant/donor site compared with non-resorbable barrier (guided bone regeneration); GRADE not reported.

1 finding from 1 review

Autogenous bone graft augmentation at the immediate implant site vs No augmentation

Major complications at the implant/donor site · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Autogenous bone graft augmentation at the immediate implant site led to lower major complications at the implant/donor site compared with no augmentation; GRADE not reported.

1 finding from 1 review

Autogenous bone graft augmentation at the immediate implant site vs No augmentation

Vertical bone gain · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Autogenous bone graft augmentation at the immediate implant site showed no clear difference in bone gain (vertical - VDH) compared with no augmentation; GRADE not reported.

1 finding from 1 review

Bio-Oss (anorganic bovine bone) vs Bovine-derived xenograft (Bio-Oss) plus resorbable barrier

Poor aesthetics measured by patient (after restoration) · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Bio-Oss (anorganic bovine bone) led to lower poor aesthetics measured by patient (after restoration) compared with bio-Oss + resorbable barrier; GRADE not reported.

1 finding from 1 review

Autogenous bone graft augmentation at the immediate implant site vs No augmentation

Bone gain (horizontal - HDD) · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Autogenous bone graft augmentation at the immediate implant site showed no clear difference in bone gain (horizontal - HDD) compared with no augmentation; GRADE not reported.

1 finding from 1 review

Bio-Oss (anorganic bovine bone) vs Bovine-derived xenograft (Bio-Oss) plus resorbable barrier

Augmentation (prosthesis/implant) failure · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Bio-Oss (anorganic bovine bone) led to lower augmentation (prosthesis/implant) failure compared with bio-Oss + resorbable barrier; GRADE not reported.

1 finding from 1 review

Bio-Oss (anorganic bovine bone) vs Bovine-derived xenograft (Bio-Oss) plus resorbable barrier

Poor aesthetics measured by dentist (3 years) · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Bio-Oss (anorganic bovine bone) led to lower poor aesthetics measured by dentist (3 years) compared with bio-Oss + resorbable barrier; GRADE not reported.

1 finding from 1 review

Chlorhexidine gel (0.2%, intrasocket) vs placebo or no treatment

Adverse events · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)
1 finding from 1 review
  • Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
    Follow-up: median 7 days
    No adverse events were reported. Six trials (673 participants) reported no adverse events from the use of chlorhexidine gel; one study (Rubio-Palau 2015) reported gastrointestinal discomfort (30, 18%), dizziness (10,…
    7 studies
    GRADE not reported

Neocone vs Alvogyl

Time to initial pain relief (minutes) · Adults (>18 years) with established dry socket following permanent tooth extraction

Neocone led to higher time to initial pain relief (minutes) compared with alvogyl; GRADE not reported.

1 finding from 1 review

Tranexamic acid (AMCA cones) vs Placebo (lactose cones)

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Tranexamic acid (AMCA cones) showed no clear difference in presence of dry socket compared with placebo (lactose cones); GRADE not reported.

1 finding from 1 review

Apernyl (acetylsalicylic acid pellet) vs placebo

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Apernyl (acetylsalicylic acid pellet) showed no clear difference in presence of dry socket compared with placebo; GRADE not reported.

1 finding from 1 review

Advanced platelet rich fibrin (A-PRF) vs No active treatment (control)

Pain (VAS cm) · Adults (>18 years) with established dry socket following permanent tooth extraction

Advanced platelet rich fibrin (A-PRF) led to lower pain (VAS cm) compared with control (no treatment); GRADE not reported.

1 finding from 1 review

SaliCept (acemannan hydrogel) vs no treatment

Pain (VAS) · Adults (>18 years) with established dry socket following permanent tooth extraction
1 finding from 1 review