Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

459 questions · 589 findings · 78 reviews · Oral Health

No studies found 64 · 10.9%GRADE not reported 366 · 62.1%Very low 90 · 15.3%Low 49 · 8.3%Moderate 10 · 1.7%High 10 · 1.7%

Rubber dam isolation and moisture control (alone or with saliva aspiration) vs Cotton rolls (with or without saliva aspiration)

Clinical evaluation of restoration's quality · Dental patients undergoing direct or indirect restorative treatment (no age or gender restriction)
1 finding from 1 review
  • Rubber dam isolation for restorative treatment in dental patients 2021 · Cochrane All outcomes
    6, 12, 18 months · Non-carious cervical lesions (composite restoration)
    Loguercio 2015: no significant differences (P>0.05) in marginal staining and marginal adaptation of NCCL restorations between rubber dam and cotton rolls/retraction cords at 6, 12 and 18 months.
    1 study · 30 participants
    GRADE not reported

Rubber dam isolation and moisture control (alone or with saliva aspiration) vs Cotton rolls (with or without saliva aspiration)

Participant acceptance/satisfaction · Dental patients undergoing direct or indirect restorative treatment (no age or gender restriction)
1 finding from 1 review
  • Rubber dam isolation for restorative treatment in dental patients 2021 · Cochrane All outcomes
    Non-carious cervical lesions (composite restoration)
    Evidence did not support higher acceptance/preference for rubber dam than cotton rolls (P = 0.85 from binomial test on 28 participants; very low-certainty evidence) (Loguercio 2015).
    1 study · 28 participants
    Very low

Laser enamel preparation alone (Er,Cr:YSGG or CO2 laser) vs Acid-etching (phosphoric acid)

Development of >=1 new carious lesion (caries incidence) · Caries-free children to young adults with premolars/molars requiring pit-and-fissure sealants

In the single study reporting it, caries incidence was 0% in both the laser-alone and acid-etching groups (ungraded, single study).

1 finding from 1 review

Er:YAG laser preparation combined with acid-etching vs Acid-etching (phosphoric acid)

Sealant retention rate (completely retained) · Children with permanent molars requiring pit-and-fissure sealants

At 12 months, Er:YAG laser combined with acid-etching significantly improved sealant retention versus acid-etching alone (OR 0.39, 95% CI 0.19 to 0.80, favouring laser+acid; ungraded, single study).

4 findings from 1 review
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Mineral trioxide aggregate (MTA) pulpotomy dressing vs Platelet-rich fibrin (PRF)

Overall success (composite of clinical and radiographic success) · Immature (young) permanent teeth with open apex and vital pulp exposed to dental caries or trauma, in children aged 6-14 years

A single RCT found no difference in pulpotomy success between MTA and platelet-rich fibrin (both 100% through 24 months; not pooled; ungraded).

1 finding from 1 review

Mineral trioxide aggregate (MTA) pulpotomy dressing vs Calcium-enriched mixture (CEM)

Overall success (composite of clinical and radiographic success) · Immature (young) permanent teeth with open apex and vital pulp exposed to dental caries or trauma, in children aged 6-14 years

A single RCT found no difference in pulpotomy success between MTA and calcium-enriched mixture (both 100% at 6 and 12 months; not pooled; ungraded).

1 finding from 1 review

Laser enamel preparation alone (Er,Cr:YSGG or CO2 laser) vs Acid-etching (phosphoric acid)

Acceptability · Caries-free children to young adults with premolars/molars requiring pit-and-fissure sealants

Both laser and acid-etching preparation were well accepted by patients (VAS, P = 1.000; ungraded, single study).

1 finding from 1 review

Laser enamel preparation alone (Er,Cr:YSGG or CO2 laser) vs Acid-etching (phosphoric acid)

Clinical (chair-side) time · Caries-free children to young adults with premolars/molars requiring pit-and-fissure sealants

Laser conditioning was reported to take less chair-side time than acid-etching in the studies that measured it, but times were not pooled (ungraded, narrative).

1 finding from 1 review

Laser enamel preparation alone (Er,Cr:YSGG or CO2 laser) vs Acid-etching (phosphoric acid)

Sealant retention rate (completely retained) · Caries-free children to young adults with premolars/molars requiring pit-and-fissure sealants

At 18 months, laser preparation alone did not differ significantly from acid-etching for sealant retention (OR 0.82, 95% CI 0.23 to 2.85; ungraded, single study, high risk of bias).

6 findings from 1 review
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Er:YAG laser preparation combined with acid-etching vs Acid-etching (phosphoric acid)

Physiological stress indicators (heart rate, oxygen saturation) · Children (ages 6-12) receiving pit-and-fissure sealants

Heart rate and oxygen saturation did not differ significantly between laser-plus-acid and acid-etching (ungraded, single study).

1 finding from 1 review

Laser enamel preparation (with or without acid-etching) vs Acid-etching (phosphoric acid)

Adverse events · Caries-free children to young adults with premolars/molars requiring pit-and-fissure sealants

No adverse events were reported in any included study (ungraded, narrative).

1 finding from 1 review

Er:YAG laser preparation combined with acid-etching vs Acid-etching (phosphoric acid)

Development of >=1 new carious lesion (caries incidence) · Children (high caries risk) with permanent molars requiring pit-and-fissure sealants

Caries incidence was 10% with laser-plus-acid versus 22% with acid-etching at 18 months, a non-significant difference (ungraded, single study).

1 finding from 1 review

Er:YAG laser preparation combined with acid-etching vs Acid-etching (phosphoric acid)

Dental anxiety (subjective and objective scores) · Children (ages 6-12) receiving pit-and-fissure sealants

Er:YAG laser preparation added to acid-etching did not increase children's dental anxiety versus acid-etching alone (P > 0.05; ungraded, single study).

1 finding from 1 review

Activator functional appliance vs Prefabricated functional myobrace appliance (PFA)

Final overjet · Adolescents (age 12 to 16 years) receiving orthodontic treatment to correct prominent upper front teeth (Class II malocclusion)

Activator functional appliance showed no clear difference in final overjet compared with prefabricated functional myobrace appliance (PFA); GRADE not reported.

1 finding from 1 review