What do systematic reviews say?

Combination of oral and topical CHM vs same oral CHM

• Chinese herbal medicine for atopic eczema 2013 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 22 participants
  Low

Mycophenolate sodium + oral steroids vs oral steroids alone

Mycophenolate sodium + oral steroids showed no clear difference in complete remission Time frame: 4 weeks compared with oral steroids alone (moderate certainty).

• Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
  RR 1.12 [0.84, 1.5]
  1 study · 114 participants
  Moderate
• Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
  RR 1.08 [0.84, 1.38]
  2 studies · 134 participants
  Moderate

Mycophenolate sodium + oral steroids vs oral steroids alone

Mycophenolate sodium + oral steroids showed no clear difference in complete or partial remission Time frame: 24 weeks to end of treatment compared with oral steroids alone (moderate certainty).

• Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
  RR 0.92 [0.75, 1.12]
  2 studies · 134 participants
  Moderate

Mycophenolate sodium + oral steroids vs oral steroids alone

Mycophenolate sodium + oral steroids showed no clear difference in relapse Time frame: 24 weeks compared with oral steroids alone (low certainty).

• Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
  RR 0.43 [0.08, 2.25]
  2 studies · 80 participants
  Low

Mycophenolate sodium + oral steroids vs oral steroids alone

Mycophenolate sodium + oral steroids showed no clear difference in adverse events: death compared with oral steroids alone (low certainty).

• Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
  RR 0.67 [0.12, 3.84]
  1 study · 116 participants
  Low

Mycophenolate sodium + oral steroids vs oral steroids alone

Mycophenolate sodium + oral steroids showed no clear difference in adverse events: acute kidney injury compared with oral steroids alone (low certainty).

• Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
  RR 0.5 [0.05, 5.36]
  1 study · 116 participants
  Low

Mycophenolate sodium + oral steroids vs oral steroids alone

Mycophenolate sodium + oral steroids showed no clear difference in adverse events: new‐onset glucose intolerance compared with oral steroids alone (low certainty).

• Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
  RR 0.2 [0.01, 4.08]
  2 studies · 136 participants
  Low

Dextrose gel vs oral (swallowed) glucose

It is very uncertain whether oral + buccal glucose (dextrose gel) changes resolution of symptoms within 20 minutes compared with oral (swallowed) glucose (very low certainty).

• First aid glucose administration routes for symptomatic hypoglycaemia 2019 · Cochrane Headline outcomes only
  RR 0.36 [0.12, 1.14]
  1 study · 18 participants
  Very low

Dextrose gel vs oral (swallowed) glucose

The review found no eligible studies for this question.

• First aid glucose administration routes for symptomatic hypoglycaemia 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Dextrose gel vs oral (swallowed) glucose

• First aid glucose administration routes for symptomatic hypoglycaemia 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 18 participants
  Very low

Dextrose gel vs oral (swallowed) glucose

The review found no eligible studies for this question.

• First aid glucose administration routes for symptomatic hypoglycaemia 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Dextrose gel vs oral (swallowed) glucose

The review found no eligible studies for this question.

• First aid glucose administration routes for symptomatic hypoglycaemia 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Dextrose gel vs oral (swallowed) glucose

The review found no eligible studies for this question.

• First aid glucose administration routes for symptomatic hypoglycaemia 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Dextrose gel vs oral (swallowed) glucose

The review found no eligible studies for this question.

• First aid glucose administration routes for symptomatic hypoglycaemia 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Dextrose gel vs control

Oral dextrose gel showed no clear difference in correction of hypoglycaemia for each hypoglycaemic event before… compared with control (moderate certainty).

• Oral dextrose gel for the treatment of hypoglycaemia in newborn infants 2022 · Cochrane Headline outcomes only
  Rate ratio 1.08 [0.98, 1.2]
  1 study · 237 participants
  Moderate

Dextrose gel vs control

Oral dextrose gel showed no clear difference in major neurological disability at age 2 years or olderb Defined as… compared with control (low certainty).

• Oral dextrose gel for the treatment of hypoglycaemia in newborn infants 2022 · Cochrane Headline outcomes only
  RR 0.46 [0.09, 2.47]
  1 study · 185 participants
  Low

Dextrose gel vs control

It is very uncertain whether oral dextrose gel changes receipt of intravenous treatment for hypoglycaemia before discharge… compared with control (very low certainty).

• Oral dextrose gel for the treatment of hypoglycaemia in newborn infants 2022 · Cochrane Headline outcomes only
  RR 0.78 [0.46, 1.32]
  2 studies · 312 participants
  Very low

Dextrose gel vs control

• Oral dextrose gel for the treatment of hypoglycaemia in newborn infants 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 237 participants
  Low

Dextrose gel vs control

Oral dextrose gel probably leads to lower separation from mother for treatment of hypoglycaemia before… compared with control (moderate certainty).

• Oral dextrose gel for the treatment of hypoglycaemia in newborn infants 2022 · Cochrane Headline outcomes only
  RR 0.54 [0.31, 0.93]
  1 study · 237 participants
  Moderate

Dextrose gel vs control

Oral dextrose gel probably leads to higher exclusive breastfeeding after discharge (WHO 2008 definition (yes/no)) compared with control (moderate certainty).

• Oral dextrose gel for the treatment of hypoglycaemia in newborn infants 2022 · Cochrane Headline outcomes only
  RR 1.1 [1.01, 1.18]
  1 study · 237 participants
  Moderate