What do systematic reviews say?

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs Low-dose leucovorin rinse

• Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy 2015 · Cochrane All outcomes
  Oral mucositis (severe). Not estimable - no participants had developed severe oral mucositis by the fourth day after chemotherapy when the data were reported (Zhang 2011, Analysis 4.3, subgroup 3.1); 118 participants…
  1 study · 118 participants
  GRADE not reported

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs Low-dose leucovorin rinse

It is very uncertain whether oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… changes oral mucositis (any severity) compared with low-dose leucovorin rinse (very low certainty).

• Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy 2015 · Cochrane All outcomes
  RR 0.67 [0.50, 0.90]
  1 study · 118 participants
  Very low

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs Low-dose leucovorin rinse

It is very uncertain whether oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… changes oral mucositis (moderate to severe) compared with low-dose leucovorin rinse (very low certainty).

• Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy 2015 · Cochrane All outcomes
  RR 0.18 [0.01, 3.42]
  1 study · 118 participants
  Very low

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs High-dose leucovorin rinse

It is very uncertain whether oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… changes oral mucositis (any severity) compared with high-dose leucovorin rinse (very low certainty).

• Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy 2015 · Cochrane All outcomes
  RR 0.65 [0.47, 0.90]
  1 study · 81 participants
  Very low

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs High-dose leucovorin rinse

• Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy 2015 · Cochrane All outcomes
  Oral mucositis (moderate to severe). Not estimable - no participants had developed moderate or severe oral mucositis by the fourth day after chemotherapy when the data were reported (Zhang 2011, Analysis 4.2, subgroup…
  1 study · 81 participants
  GRADE not reported

Self etching primer (one-step etchant-and-primer technique) vs Conventional etchants (two-step etch and prime method using 37% phosphoric acid)

The review found no eligible studies for this question.

• Enamel etching for bonding fixed orthodontic braces 2013 · Cochrane All outcomes
  Cost of treatment: No studies assessed this outcome.
  Studies not reported
  No studies found

Self etching primer (one-step etchant-and-primer technique) vs Conventional etchants (two-step etch and prime method using 37% phosphoric acid)

The review found no eligible studies for this question.

• Enamel etching for bonding fixed orthodontic braces 2013 · Cochrane All outcomes
  Damage to the teeth: No studies assessed this outcome.
  Studies not reported
  No studies found

Self etching primer (one-step etchant-and-primer technique) vs Conventional etchants (two-step etch and prime method using 37% phosphoric acid)

Self etching primers (one-step etchant and primer system) showed no clear difference in bond failure rate compared with conventional etchants (two-step etch and prime method using 37%… (low certainty).

• Enamel etching for bonding fixed orthodontic braces 2013 · Cochrane All outcomes

  5 to 37 months
  RR 1.14 [0.75, 1.73]
  5 studies · 221 participants
  Low

Self etching primer (one-step etchant-and-primer technique) vs Conventional etchants (two-step etch and prime method using 37% phosphoric acid)

The review found no eligible studies for this question.

• Enamel etching for bonding fixed orthodontic braces 2013 · Cochrane All outcomes
  Participant satisfaction: No studies assessed this outcome.
  Studies not reported
  No studies found

Self etching primer (one-step etchant-and-primer technique) vs Conventional etchants (two-step etch and prime method using 37% phosphoric acid)

• Enamel etching for bonding fixed orthodontic braces 2013 · Cochrane All outcomes
  Decay (decalcification) associated with or around the etching field: Only one study (Ghiz 2009) assessed this outcome but data were reported at the tooth level rather than at the participant level and therefore was not…
  1 study · 25 participants
  GRADE not reported

Fluticasone propionate spray vs Betamethasone sodium phosphate mouthwash

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  No statistical testing of the Oral Health Quality of Life index (OHQoL16) was reported in Hegarty 2002 (fluticasone mean score 0.7 versus betamethasone mean score -0.8).
  1 study · 22 participants
  GRADE not reported

Intra-articular injection of sodium hyaluronate vs corticosteroid injection

Intra-articular injection of sodium hyaluronate showed no clear difference in complications (adverse effects) compared with intra-articular injection of corticosteroids (betamethasone); GRADE not reported.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes
  RR 1.20 [0.44, 3.30]
  1 study · 40 participants
  GRADE not reported

Intra-articular injection of sodium hyaluronate vs corticosteroid injection

Intra-articular injection of sodium hyaluronate led to lower presence of TMJ sounds compared with intra-articular injection of corticosteroids (betamethasone); GRADE not reported.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes

  14 days
  RR 0.59 [0.37, 0.95]
  1 study · 40 participants
  GRADE not reported

Fluticasone propionate spray vs Betamethasone sodium phosphate mouthwash

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  In the Hegarty 2002 cross-over trial (n=22), no statistical testing of the pain score (VAS 0 to 100) was reported; it is not clear whether the difference is statistically significant (fluticasone mean score 19.8 versus…
  1 study · 22 participants
  GRADE not reported

Fluticasone propionate spray vs Betamethasone sodium phosphate mouthwash

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  No statistical testing of the mean surface area of lesions was reported in Hegarty 2002 (fluticasone mean score 547.2 mm2 versus betamethasone mean score 671.9 mm2).
  1 study · 22 participants
  GRADE not reported

Intra-articular injection of sodium hyaluronate vs corticosteroid injection

Intra-articular injection of sodium hyaluronate led to lower pain on palpation of the affected/contralateral TMJ and masticatory… compared with intra-articular injection of corticosteroids (betamethasone); GRADE not reported.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes

  14 days to 6 months
  Pain on palpation of the affected and contralateral TMJ and masticatory muscles presented similar frequencies regardless of the time (Analyses 1.4-1.12); no statistically significant differences reported. Point…
  1 study · 40 participants
  GRADE not reported

Intra-articular injection of sodium hyaluronate vs corticosteroid injection

Intra-articular injection of sodium hyaluronate showed no clear difference in extent of mandibular movement (maximum jaw opening, lateral and… compared with intra-articular injection of corticosteroids (betamethasone); GRADE not reported.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes

  14 days to 6 months
  None of the mean differences between interventions for the measures of jaw movements (maximum jaw opening, lateral movement to affected side, contralateral movement, jaw protrusion; Analyses 1.16-1.27) showed…
  1 study · 40 participants
  GRADE not reported

Fluticasone propionate spray vs Betamethasone sodium phosphate mouthwash

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  Table 3 (Side-effects). Hegarty 2002: nausea (4), swollen mouth (1), bad taste and smell (6), difficulty in spray application (7), dry mouth (2), sore throat (1), red painful tongue (1), and pseudomembranous…
  1 study · 44 participants
  GRADE not reported

Zirconia framework FDP vs Metal framework FDP

• Interventions for replacing missing teeth: partially absent dentition 2012 · Cochrane All outcomes

  3 years
  100% survival and no framework fractures in either group after 3 years; no significant differences between groups with respect to porcelain fractures and mean survival time (narrative)
  1 study
  GRADE not reported

Intra-articular injection of sodium hyaluronate vs corticosteroid injection

Intra-articular injection of sodium hyaluronate led to lower reported pain (mm on VAS) compared with intra-articular injection of corticosteroids (betamethasone); GRADE not reported.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes

  6 months
  MD -17.00 [-32.60, -1.40]
  1 study · 40 participants
  GRADE not reported