Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,038 questions · 2,118 findings · 339 reviews

No studies found 323 · 15.3%GRADE not reported 166 · 7.8%Very low 552 · 26.1%Low 592 · 28%Moderate 340 · 16.1%High 145 · 6.8%

Steroids vs lubricants

Change in tear osmolarity (mOsm/kg) (lower is favored) · people with dry eye

It is very uncertain whether steroids changes change in tear osmolarity (mOsm/kg) (lower is favored) compared with lubricants (very low certainty).

1 finding from 1 review

Steroids vs cyclosporine A

Change in patient‐reported symptom scores (lower is favored) · people with dry eye

Steroids showed no clear difference in change in patient‐reported symptom scores (lower is favored) compared with cyclosporine A (low certainty).

1 finding from 1 review

Lacebacks with fixed appliances vs Fixed appliances

Size of the lower jaw (arch length) · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

Lacebacks with fixed appliances showed no clear difference in size of the lower jaw (arch length) compared with fixed appliances only (control); GRADE not reported.

1 finding from 1 review

Schwarz appliance vs No active treatment (control)

Size of the lower jaw (arch length, change) · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

Schwarz appliance showed no clear difference in size of the lower jaw (mandibular arch length, change) at 9 months compared with no active treatment (control); GRADE not reported.

1 finding from 1 review

Cervical pull headgear vs Minor interceptive procedures (control)

Amount of crowding (lower incisor crowding) at 10 weeks · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

It is very uncertain whether cervical pull headgear changes amount of crowding (lower incisor crowding) at 2 years compared with minor interceptive procedures (control) (very low certainty).

1 finding from 1 review

Schwarz appliance vs No active treatment (control)

Amount of crowding (change in mandibular crowding) at 8 weeks · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

It is very uncertain whether schwarz appliance changes amount of crowding (lower arch crowding, change) at 9 months compared with no active treatment (control) (very low certainty).

1 finding from 1 review

Self-ligating brackets vs Conventional brackets

Lower incisor inclination (lingual tipping and retrusion) · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

Self-ligating brackets showed no clear difference in lower incisors to mandible (inclination, degrees) compared with conventional brackets; GRADE not reported.

1 finding from 1 review

Lay health worker‐led psychological interventions vs usual care

Prevalence of CMDs ‐ intermediate term (1 to 6 months post intervention) Diagnosis defined by SRQ‐20 > 7b; PHQ‐9 ≥ 11d (RR < 1 denotes lower prevalence compared to control) · adults with common mental disorders

Lay health worker‐led psychological interventions may leads to lower prevalence of CMDs ‐ intermediate term (1 to 6 months post… compared with usual care (low certainty).

1 finding from 1 review

Lay health worker‐led psychological interventions vs usual care

Prevalence of PTSD · adults with post‐traumatic stress and CMDs

It is very uncertain whether lay health worker‐led psychological interventions changes prevalence of PTSD ‐ intermediate term (1 to 6 months) Diagnosis… compared with usual care (very low certainty).

1 finding from 1 review

Primary health professional‐led psychological interventions vs usual care or no treatment

Prevalence of adults with probable PTSD (1 to 6 months post intervention) Diagnosis defined by HTQ ≥ 1.75 (RR > 1 denotes lower prevalence compared to control) · adults with post‐traumatic stress or common mental disorders

Primary health professional‐led psychological interventions may leads to higher prevalence of adults with probable PTSD (1 to 6 months post… compared with usual or no care (low certainty).

1 finding from 1 review

Primary health professional‐led psychological interventions vs usual care or no treatment

Anxiety and depression · adults with post‐traumatic stress or common mental disorders

Primary health professional‐led psychological interventions may leads to higher prevalence of adults with probable depression or anxiety (1 to 6… compared with usual or no care (low certainty).

1 finding from 1 review

Lay health worker‐led interventions for adult patients with harmful or hazardous alcohol or substance use vs enhanced usual care

Prevalence of methamphetamine use (1 to 6 months post intervention) (RR < 1 denotes lower prevalence compared to control) · adult patients with harmful or hazardous alcohol or substance use

Lay health worker‐led interventions for adult patients with harmful… showed no clear difference in prevalence of methamphetamine use (1 to 6 months post intervention)… compared with enhanced usual care (low certainty).

1 finding from 1 review

Lay health worker‐led interventions for adult patients with harmful or hazardous alcohol or substance use vs enhanced usual care

Service utilisation ‐ unplanned hospitalisations (1 to 6 months post intervention) (RR < 1 denotes lower risk) · adult patients with harmful or hazardous alcohol or substance use

It is very uncertain whether lay health worker‐led interventions for adult patients with harmful… changes service utilisation ‐ unplanned hospitalisations (1 to 6 months post… compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐led interventions for adult patients with harmful or hazardous alcohol or substance use vs enhanced usual care

Adverse events ‐ death in past 12 months (RR > 1 denotes higher risk of death) · adult patients with harmful or hazardous alcohol or substance use

It is very uncertain whether lay health worker‐led interventions for adult patients with harmful… changes adverse events ‐ deaths (RR < 1 denotes lower risk) compared with enhanced usual care (very low certainty).

1 finding from 1 review

Primary health professional‐ and community professional‐led interventions vs enhanced usual care

Cannabis use · adult patients with harmful or hazardous alcohol or substance use

It is very uncertain whether primary health professional‐ and community professional‐led… changes prevalence of cannabis use (1 to 6 months post intervention) (RR < 1… compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐led psychological interventions vs usual care

Adverse events RR < 1 indicates lower risk of adverse events · adults with common mental disorders

Lay health worker‐led psychological interventions may leads to lower adverse events RR < 1 indicates lower risk of adverse events compared with usual care (low certainty).

1 finding from 1 review