Findings

What do systematic reviews say?

360 questions · 382 findings · 30 reviews · Airways

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No studies found 50 · 13.1%GRADE not reported 40 · 10.5%Very low 64 · 16.8%Low 104 · 27.2%Moderate 97 · 25.4%High 27 · 7.1%

Human deoxyribonuclease vs placebo

Clinical failure Number of children with no significant improvement in cough diary scores at two weeks (average of day 13 to 14) · children with primary (intrinsic) tracheomalacia

Human deoxyribonuclease showed no clear difference in clinical failure Number of children with no significant improvement… compared with placebo (low certainty).

1 finding from 1 review

Interventions for primary (intrinsic) tracheomalacia in children 2012 · Cochrane Headline outcomes only
OR 1.38 [0.37, 5.14]
1 study · 38 participants
Low

Human deoxyribonuclease vs placebo

Cough · children with primary (intrinsic) tracheomalacia

1 finding from 1 review

Interventions for primary (intrinsic) tracheomalacia in children 2012 · Cochrane Headline outcomes only
no estimate extracted
1 study · 38 participants
Low

Human deoxyribonuclease vs placebo

Night time cough diary score (change from baseline) · children with primary (intrinsic) tracheomalacia

1 finding from 1 review

Interventions for primary (intrinsic) tracheomalacia in children 2012 · Cochrane Headline outcomes only
no estimate extracted
1 study · 38 participants
Low

Human deoxyribonuclease vs placebo

Night time VAS (change from baseline) · children with primary (intrinsic) tracheomalacia

1 finding from 1 review

Interventions for primary (intrinsic) tracheomalacia in children 2012 · Cochrane Headline outcomes only
no estimate extracted
1 study · 38 participants
Low

Human deoxyribonuclease vs placebo

Difficulty expectorating sputum score (change from baseline) · children with primary (intrinsic) tracheomalacia

1 finding from 1 review

Interventions for primary (intrinsic) tracheomalacia in children 2012 · Cochrane Headline outcomes only
no estimate extracted
1 study · 38 participants
Low

Human deoxyribonuclease vs placebo

FVC (% predicted) Change from baseline · children with primary (intrinsic) tracheomalacia

1 finding from 1 review

Interventions for primary (intrinsic) tracheomalacia in children 2012 · Cochrane Headline outcomes only
no estimate extracted
1 study · 27 participants
Low

Human deoxyribonuclease vs placebo

FEV1 · children with primary (intrinsic) tracheomalacia

1 finding from 1 review

Interventions for primary (intrinsic) tracheomalacia in children 2012 · Cochrane Headline outcomes only
no estimate extracted
1 study · 27 participants
Low

Education vs control

Exacerbations leading to ED visits · children with asthma

1 finding from 1 review

Home‐based educational interventions for children with asthma 2011 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 985 participants
Very low

Education vs control

Mean exacerbations requiring a course of oral corticosteroids · children with asthma

1 finding from 1 review

Home‐based educational interventions for children with asthma 2011 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 500 participants
Very low

Education vs other home‐based education

Exacerbations leading to ED visits · patients with children with asthma

1 finding from 1 review

Home‐based educational interventions for children with asthma 2011 · Cochrane Headline outcomes only
no estimate extracted
1 study · 181 participants
Very low

Education vs other home‐based education

Mean exacerbations requiring a course of oral corticosteroids · patients with children with asthma

1 finding from 1 review

Home‐based educational interventions for children with asthma 2011 · Cochrane Headline outcomes only
no estimate extracted
1 study · 193 participants
Very low

Intervention not reported

Number of subjects who had one or more exacerbations over the study period in adults ( · Adults and children with asthma

The intervention showed no clear difference in number of subjects who had one or more exacerbations over the study… (moderate certainty).

1 finding from 1 review

Tailored interventions based on exhaled nitric oxide versus clinical symptoms for asthma in children and adults 2009 · Cochrane Headline outcomes only
OR 0.85 [0.3, 2.43]
2 studies · 197 participants
Moderate

Intervention not reported

Number of subjects who had one or more exacerbations over the study period in children and adolescents ( · Adults and children with asthma

The intervention showed no clear difference in number of subjects who had one or more exacerbations over the study… (moderate certainty).

1 finding from 1 review

Tailored interventions based on exhaled nitric oxide versus clinical symptoms for asthma in children and adults 2009 · Cochrane Headline outcomes only
OR 0.75 [0.55, 1.01]
3 studies · 782 participants
Moderate

Intervention not reported

Number of exacerbations per 52 weeks in adults ( · Adults and children with asthma

1 finding from 1 review

Tailored interventions based on exhaled nitric oxide versus clinical symptoms for asthma in children and adults 2009 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 197 participants
Moderate

Intervention not reported

Number of exacerbations per 52 weeks in children and adolescents ( · Adults and children with asthma

1 finding from 1 review

Tailored interventions based on exhaled nitric oxide versus clinical symptoms for asthma in children and adults 2009 · Cochrane Headline outcomes only
no estimate extracted
1 study · 546 participants
Moderate

Intervention not reported

ICS dose at final visit in adults ( · Adults and children with asthma

1 finding from 1 review

Tailored interventions based on exhaled nitric oxide versus clinical symptoms for asthma in children and adults 2009 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 197 participants
Moderate

Intervention not reported

ICS dose at final visit in children and adolescents ( · Adults and children with asthma

1 finding from 1 review

Tailored interventions based on exhaled nitric oxide versus clinical symptoms for asthma in children and adults 2009 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 777 participants
Low

Intervention not reported

Hospital admission/re‐admission · Adults who attend the emergency room for acute asthma

The intervention leads to lower hospital admission/re‐admission (high certainty).

1 finding from 1 review

Education interventions for adults who attend the emergency room for acute asthma 2007 · Cochrane Headline outcomes only
RR 0.5 [0.27, 0.91]
5 studies · 572 participants
High

Intervention not reported

Presentation at emergency department · Adults who attend the emergency room for acute asthma

The intervention showed no clear difference in presentation at emergency department (low certainty).

1 finding from 1 review

Education interventions for adults who attend the emergency room for acute asthma 2007 · Cochrane Headline outcomes only
RR 0.72 [0.47, 1.11]
8 studies · 946 participants
Low

Intervention not reported

Quality of life (SGRQ) ‐ Total scores SGRQ units. Scale from: 0 to 100. · Adults who attend the emergency room for acute asthma

1 finding from 1 review

Education interventions for adults who attend the emergency room for acute asthma 2007 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 356 participants
Low