Intervention not reported
Time to 12‐month remission ‐ stratified by seizure type ‐ Partial Onset Range of · adults and children with newly diagnosed partial onset or generalised onset seizures
The intervention showed no clear difference in time to 12‐month remission ‐ stratified by seizure type ‐ Partial… (moderate certainty).
1 finding from 1 review
Intervention not reported
Time to 6‐month remission ‐ all participants Range of · adults and children with newly diagnosed partial onset or generalised onset seizures
The intervention showed no clear difference in time to 6‐month remission ‐ all participants Range of (moderate certainty).
1 finding from 1 review
Intervention not reported
Time to 6‐month remission ‐ stratified by seizure type ‐ Partial onset Range of · adults and children with newly diagnosed partial onset or generalised onset seizures
The intervention showed no clear difference in time to 6‐month remission ‐ stratified by seizure type ‐ Partial… (moderate certainty).
1 finding from 1 review
Intervention not reported
Comparison (reference treatment) · adults and children with generalised seizures*
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Sodium valproate · adults and children with generalised seizures*
1 finding from 1 review
Intervention not reported
Any reason · adults and children with generalised tonic‐clonic seizures with or without other seizure types
1 finding from 1 review
Intervention not reported
Adverse events · adults and children with generalised tonic‐clonic seizures with or without other seizure types
1 finding from 1 review
Intervention not reported
Lack of efficacy · adults and children with generalised tonic‐clonic seizures with or without other seizure types
1 finding from 1 review
Remission (response plus end score 8 or less) · adults with seasonal affective disorder
It is very uncertain whether fluoxetine changes remission (response plus end score 8 or less) compared with light therapy (very low certainty).
1 finding from 1 review
Speed of onset of response · adults with seasonal affective disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse events ‐ treatment emergent · adults with seasonal affective disorder
Fluoxetine showed no clear difference in adverse events (at least 1 treatment‐emergent adverse event) compared with light therapy (low certainty).
1 finding from 1 review
Response (> 50% improvement on 24‐item HAM‐D SIGH‐SAD) · adults with seasonal affective disorder
Fluoxetine showed no clear difference in response (> 50% improvement on 24‐item HAM‐D SIGH‐SAD) compared with light therapy (low certainty).
1 finding from 1 review
Clinical Global Impressions ‐ Improvement of condition (CGI‐I) Rating of 1 = very much improved to 7 = very much worse · adults with seasonal affective disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Quality of life (SF‐20 & Q‐LES‐Q) Eight weeks · adults with seasonal affective disorder
1 finding from 1 review
Time to treatment failure (any reason related to treatment) All participants Range of · adults and children with newly onset partial or generalised epilepsy
Carbamazepine showed no clear difference in time to treatment failure (any reason related to treatment)All… compared with phenytoin (time to treatment failure) (moderate certainty).
1 finding from 1 review
Time to treatment failure (any reason related to treatment) Subgroup: focal onset seizures Range of · adults and children with newly onset partial or generalised epilepsy
Carbamazepine showed no clear difference in time to treatment failure (any reason related to treatment)… compared with phenytoin (time to treatment failure) (moderate certainty).
1 finding from 1 review
Time to first seizure (post‐randomisation) All participants Range of · adults and children with newly onset partial or generalised epilepsy
Carbamazepine showed no clear difference in time to first seizure after randomisationAll participants Range of compared with phenytoin (secondary outcomes) (moderate certainty).
1 finding from 1 review
Time to first seizure (post‐randomisation) Subgroup: focal onset seizures Range of · adults and children with newly onset partial or generalised epilepsy
Carbamazepine showed no clear difference in time to first seizure after randomisation Subgroup: focal onset… compared with phenytoin (secondary outcomes) (moderate certainty).
1 finding from 1 review
Time to achieve 12‐month remissionAll participants Range of · adults and children with newly onset partial or generalised epilepsy
Carbamazepine showed no clear difference in time to achieve 12‐month remissionAll participants Range of compared with phenytoin (secondary outcomes) (moderate certainty).
1 finding from 1 review
Time to achieve 12‐month remission (seizure‐free period) Subgroup: focal onset seizures Range of · adults and children with newly onset partial or generalised epilepsy
Carbamazepine showed no clear difference in time to achieve 12‐month remissionSubgroup: focal onset seizures… compared with phenytoin (secondary outcomes) (moderate certainty).
1 finding from 1 review