Cochrane · systematic review · CD001911
Carbamazepine versus phenytoin monotherapy for epilepsy: an individual participant data review
Nevitt, SJ, Marson, AG, Tudur Smith, C · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
9
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 33.3%Moderate 6 · 66.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 3 versionsCarbamazepine compared with phenytoin (time to treatment failure)
Population: adults and children with new‐onset focal or generalised epilepsy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Time to treatment failure (any reason related to treatment)All participants Range of Carbamazepine vs phenytoin (time to treatment failure) | HR 0.94 [0.7, 1.26] | 3 studies · 546 participants | Moderate Downgraded: risk of bias, indirectness |
Time to treatment failure (any reason related to treatment) Subgroup: focal onset seizures Range of Carbamazepine vs phenytoin (time to treatment failure) | HR 0.83 [0.61, 1.13] | 3 studies · 428 participants | Moderate Downgraded: risk of bias, indirectness |
Time to treatment failure (any reason related to treatment) Subgroup: generalisedonset tonic clonic seizures Range of Carbamazepine vs phenytoin (time to treatment failure) | HR 2.38 [1.04, 5.47] | 2 studies · 118 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Carbamazepine compared with phenytoin (secondary outcomes)
Population: adults and children with new‐onset focal or generalised epilepsy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Time to first seizure after randomisationAll participants Range of Carbamazepine vs phenytoin (secondary outcomes) | HR 1.15 [0.94, 1.4] | 4 studies · 582 participants | Moderate Downgraded: risk of bias |
Time to first seizure after randomisation Subgroup: focal onset seizures Range of Carbamazepine vs phenytoin (secondary outcomes) | HR 1.13 [0.89, 1.43] | 4 studies · 432 participants | Moderate Downgraded: risk of bias |
Time to first seizure after randomisationSubgroup: generalisedonset tonic clonic seizures Range of Carbamazepine vs phenytoin (secondary outcomes) | HR 1.19 [0.81, 1.75] | 3 studies · 150 participants | Low Downgraded: risk of bias, inconsistency |
Time to achieve 12‐month remissionAll participants Range of Carbamazepine vs phenytoin (secondary outcomes) | HR 1 [0.79, 1.26] | 3 studies · 551 participants | Moderate Downgraded: risk of bias |
Time to achieve 12‐month remissionSubgroup: focal onset seizures Range of Carbamazepine vs phenytoin (secondary outcomes) | HR 1.06 [0.8, 1.42] | 3 studies · 430 participants | Moderate Downgraded: risk of bias |
Time to achieve 12‐month remissionSubgroup: generalisedonset tonic clonic seizures Range of Carbamazepine vs phenytoin (secondary outcomes) | HR 0.88 [0.58, 1.33] | 2 studies · 121 participants | Low Downgraded: risk of bias, inconsistency |