Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

407 questions · 500 findings · 40 reviews

No studies found 115 · 23%GRADE not reported 185 · 37%Very low 89 · 17.8%Low 63 · 12.6%Moderate 36 · 7.2%High 12 · 2.4%

Moxifloxacin + SRP vs SRP

Percentage of bleeding on probing (BOP) · Adults with chronic periodontitis

Moxifloxacin + SRP led to lower percentage of bleeding on probing (BOP) compared with SRP; GRADE not reported.

2 findings from 1 review

Azithromycin + SRP vs SRP

Adverse events · Adults with periodontitis (chronic and aggressive)

It is very uncertain whether azithromycin + SRP changes adverse events compared with SRP (very low certainty).

1 finding from 1 review

Amoxicillin + metronidazole + SRP vs SRP

Adverse events · Adults with periodontitis (chronic and aggressive)

It is very uncertain whether amoxicillin + metronidazole + SRP changes adverse events compared with SRP (very low certainty).

1 finding from 1 review

Levofloxacin + SRP vs SRP

Clinical attachment level (CAL) · Adults with chronic periodontitis

Levofloxacin + SRP led to lower clinical attachment level (CAL) compared with SRP; GRADE not reported.

2 findings from 1 review

Doxycycline + SRP vs Amoxicillin + metronidazole + SRP

Adverse events · Adults with aggressive periodontitis

Doxycycline + SRP showed no clear difference in adverse events compared with amoxicillin + metronidazole + SRP; GRADE not reported.

1 finding from 1 review

Tetracycline + SRP vs SRP

Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis

The review found no eligible studies for this question.

2 findings from 1 review

Oral or topical or intraperitoneal antibiotics vs placebo/no treatment

Peritonitis · chronic peritoneal dialysis patients

Oral or topical or intraperitoneal antibiotics showed no clear difference in peritonitis (number of patients with one or more episodes) compared with placebo/no treatment (low certainty).

1 finding from 1 review

Any antifungal intervention for the treatment of oral candidiasis vs placebo/no treatment

Fungal peritonitis (number of patients with one or more episodes) · chronic peritoneal dialysis patients

Antifungal may leads to lower fungal peritonitis (number of patients with one or more episodes) compared with placebo/no treatment (low certainty).

1 finding from 1 review

Oral or topical or intraperitoneal antibiotics vs placebo/no treatment

Exit‐site/tunnel infection · chronic peritoneal dialysis patients

Oral or topical or intraperitoneal antibiotics showed no clear difference in exit‐site/tunnel infection (number of patients with one or more… compared with placebo/no treatment (low certainty).

1 finding from 1 review

Oral or topical or intraperitoneal antibiotics vs placebo/no treatment

Catheter removal or replacement · chronic peritoneal dialysis patients

Oral or topical or intraperitoneal antibiotics showed no clear difference in catheter removal or replacement (number of patients) compared with placebo/no treatment (low certainty).

1 finding from 1 review