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Evidence found and GRADE certainty

4,411 questions · 5,986 findings · 226 reviews · Oral Health

No studies found 1,305 · 21.8%GRADE not reported 2,988 · 49.9%Very low 1,030 · 17.2%Low 476 · 8%Moderate 156 · 2.6%High 31 · 0.5%

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Sucralfate suspension (topical) vs Placebo suspension

Duration of episodes · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care

Sucralfate suspension (topical) showed no clear difference in mean duration of episodes compared with placebo suspension; GRADE not reported.

1 finding from 1 review

Low‐level laser therapy vs Placebo (sham) laser therapy

Patient-reported altered sensation (spontaneous or evoked: anaesthesia/paraesthesia/dysaesthesia/hyperalgesia/allodynia) · Patients of any age in any setting requiring intervention for iatrogenic injury to the inferior alveolar or lingual nerve

It is very uncertain whether low-level laser therapy (photon-plus GaAlAs diode laser; 70 mW… changes patient-reported altered sensation (spontaneous or evoked:… compared with placebo (sham) laser therapy (very low certainty).

2 findings from 1 review

One-stage lateral sinus lift with monocortical autogenous bone blocks (iliac crest) vs Two-stage lateral sinus lift with autogenous particulate bone (iliac crest)

Complication (perforation of sinus membrane) at augmented site · Patients with 2 to 7 mm of residual alveolar bone height in the edentulous maxillary sinus floor

One-stage lateral sinus lift with monocortical autogenous bone… showed no clear difference in complications (sinus membrane perforation) compared with two-stage lateral sinus lift with autogenous particulate bone (iliac…; GRADE not reported.

1 finding from 1 review

Low‐level laser therapy vs Placebo (sham) laser therapy

Somatosensory evoked potentials · Patients of any age in any setting requiring intervention for iatrogenic injury to the inferior alveolar or lingual nerve

The review found no eligible studies for this question.

1 finding from 1 review

Early loading of mini-screw implant vs Delayed loading of mini-screw implant

Success of the anchorage device · Patients undergoing orthodontic treatment requiring surgical (mini-screw implant) anchorage

Early loading of mini-screw implant showed no clear difference in success of the anchorage device compared with delayed loading of mini-screw implant; GRADE not reported.

1 finding from 1 review

Interferon-alpha (topical lozenges) vs placebo

Total ulcer burden · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • Kilic 2009 (interferon-alpha lozenges 1000 IU or 2000 IU vs placebo, 84 patients; high risk of selective reporting): the data presented did not allow analysis; authors reported no statistically significant difference…
    1 study · 84 participants
    GRADE not reported

Frankel's function regulator-4 (FR-4) with lip-seal training vs no treatment

Reduction or treatment of obstructive sleep apnoea syndrome (OSAS) or upper airway resistance syndrome (UARS) · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…

The review found no eligible studies for this question.

1 finding from 1 review

NobelActive external connection implants vs NobelActive internal connection implants

Marginal bone level change · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year

NobelActive external connection implants showed no clear difference in marginal bone level change compared with nobelActive internal connection implants; GRADE not reported.

1 finding from 1 review

IMZ TPS titanium cylinders vs ITI TPS hollow titanium screws

Implant failure · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year

IMZ TPS titanium cylinders showed no clear difference in implant failure compared with ITI TPS hollow titanium screws; GRADE not reported.

1 finding from 1 review

Systemic interventions (aciclovir, thalidomide, corticosteroids, rebamipide, etanercept, colchicine, interferon-alpha) vs placebo

Episode duration associated with oral ulcers · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • SoF 2 (systemic interventions vs placebo), grouped comment spanning all four listed outcomes (verbatim; the review's wording "topical" is a typo for systemic): "8 placebo-controlled trials evaluated topical…
    Studies not reported
    GRADE not reported

Removable appliance with palatal crib associated with high-pull chincup vs no treatment

Mandibular ramus growth · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…
1 finding from 1 review
  • Orthodontic and orthopaedic treatment for anterior open bite in children 2014 · Cochrane All outcomes
    End of treatment (12 months)
    Cephalometric data (SNA, Co-A, SNB, Ar-Go, Ar.GoMe, Co-Gn, ANB) were reported to be not significantly different between groups; effects were dento-alveolar rather than skeletal. No pooled estimate (Almeida 2005).
    1 study
    GRADE not reported

Branemark turned titanium screws vs IMZ TPS titanium cylinders

Implant failure · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year

Branemark turned titanium screws showed no clear difference in implant failure compared with IMZ TPS titanium cylinders; GRADE not reported.

1 finding from 1 review

NobelReplace Select Tapered implants vs NobelReplace implants

Implant failure · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year

NobelReplace Select Tapered implants showed no clear difference in implant failure compared with nobelReplace Groovy implants; GRADE not reported.

1 finding from 1 review

Autogenous bone graft (two-stage lateral sinus lift) vs Bone substitute (anorganic bovine bone / Bio-Oss)

Complications · Patients with an atrophic posterior maxilla requiring maxillary sinus augmentation

Autogenous bone graft (two-stage lateral sinus lift) showed no clear difference in complications compared with bone substitute (anorganic bovine bone / Bio-Oss); GRADE not reported.

1 finding from 1 review

Topical triamcinolone acetonide vs Phenytoin syrup mouthwash (30 mg in 5 mL)

Positive response (not defined) · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care

Triamcinolone acetonide 0.1% ointment (topical) led to higher positive response (not defined) compared with phenytoin syrup mouthwash (30 mg in 5 mL); GRADE not reported.

1 finding from 1 review