Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,756 questions · 13,493 findings · 1,305 reviews · Headline outcomes only

No studies found 2,594 · 19.2%GRADE not reported 728 · 5.4%Very low 2,868 · 21.3%Low 3,777 · 28%Moderate 2,620 · 19.4%High 906 · 6.7%

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Coenzyme Q10 vs placebo or conventional therapy

Heart failure hospitalisation (RR) · patients with heart failure

Coenzyme Q10 probably leads to lower hospitalisation for heart failure compared with placebo or conventional therapy (moderate certainty).

1 finding from 1 review

Any dose of lacosamide vs placebo

50% or greater reduction in seizure frequency · adults and children with drug‐resistant focal epilepsy

Any dose of lacosamide leads to higher 50% or greater reduction in seizure frequency compared with placebo (high certainty).

1 finding from 1 review