What do systematic reviews say?

Summary of findings ‐ dual therapy: tezacaftor plus ivacaftor vs placebo or ivacaftor alone

• Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 946 participants
  Low

Summary of findings ‐ dual therapy: tezacaftor plus ivacaftor vs placebo or ivacaftor alone

• Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 944 participants
  Low

Summary of findings ‐ dual therapy: tezacaftor plus ivacaftor vs placebo or ivacaftor alone

• Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 944 participants
  Low

Summary of findings ‐ dual therapy: tezacaftor plus ivacaftor vs placebo or ivacaftor alone

• Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  8 studies · 1057 participants
  Moderate

Summary of findings ‐ dual therapy: tezacaftor plus ivacaftor vs placebo or ivacaftor alone

• Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 506 participants
  Moderate

Summary of findings table ‐ Structured exercise interventions vs usual care with or without sham interventions

• Exercise for acutely hospitalised older medical patients 2022 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 648 participants
  Low

Summary of findings table ‐ Structured exercise interventions vs usual care with or without sham interventions

• Exercise for acutely hospitalised older medical patients 2022 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 416 participants
  Very low

Summary of findings table ‐ Structured exercise interventions vs usual care with or without sham interventions

• Exercise for acutely hospitalised older medical patients 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 100 participants
  GRADE not reported

Summary of findings table ‐ Structured exercise interventions vs usual care with or without sham interventions

• Exercise for acutely hospitalised older medical patients 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 76 participants
  GRADE not reported

Summary of findings table ‐ Structured exercise interventions vs usual care with or without sham interventions

Summary of findings table ‐ Structured exercise interventions showed no clear difference in falls during hospitalisation compared with usual care with or without sham interventions (low certainty).

• Exercise for acutely hospitalised older medical patients 2022 · Cochrane Headline outcomes only
  RR 0.76 [0.23, 2.53]
  3 studies · 542 participants
  Low

Summary of findings table ‐ Structured exercise interventions vs usual care with or without sham interventions

It is very uncertain whether summary of findings table ‐ Structured exercise interventions changes medical deterioration during hospitalisation compared with usual care with or without sham interventions (very low certainty).

• Exercise for acutely hospitalised older medical patients 2022 · Cochrane Headline outcomes only
  RR 2.56 [0.48, 13.54]
  2 studies · 200 participants
  Very low

Summary of findings table ‐ Structured exercise interventions vs usual care with or without sham interventions

• Exercise for acutely hospitalised older medical patients 2022 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Summary of findings table ‐ Pressure sensors in bed and chair vs usual care

• Interventions for preventing and reducing the use of physical restraints of older people in general hospital settings 2022 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Summary of findings table ‐ Pressure sensors in bed and chair vs usual care

Summary of findings table ‐ Pressure sensors in bed and chair showed no clear difference in falls compared with usual care (low certainty).

• Interventions for preventing and reducing the use of physical restraints of older people in general hospital settings 2022 · Cochrane Headline outcomes only
  RR 1.33 [0.31, 5.79]
  1 study · 180 participants
  Low

Summary of findings table ‐ Pressure sensors in bed and chair vs usual care

• Interventions for preventing and reducing the use of physical restraints of older people in general hospital settings 2022 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Summary of findings table ‐ Pressure sensors in bed and chair vs usual care

• Interventions for preventing and reducing the use of physical restraints of older people in general hospital settings 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 180 participants
  Moderate

Summary of findings table ‐ Pressure sensors in bed and chair vs usual care

• Interventions for preventing and reducing the use of physical restraints of older people in general hospital settings 2022 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Summary of findings table ‐ Pressure sensors in bed and chair vs usual care

• Interventions for preventing and reducing the use of physical restraints of older people in general hospital settings 2022 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Summary of findings table ‐ Pressure sensors in bed and chair vs usual care

• Interventions for preventing and reducing the use of physical restraints of older people in general hospital settings 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 180 participants
  Moderate

Summary of findings table ‐ Intraperitoneal local anaesthetic vs control

• Intraperitoneal local anaesthetic instillation versus no intraperitoneal local anaesthetic instillation for… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  8 studies · 446 participants
  Very low