Progression‐free survival · People with squamous cell carcinoma of the oral cavity or oropharynx
EGFR monoclonal antibody (cetuximab or nimotuzumab) plus standard… showed no clear difference in progression-free survival compared with standard therapy alone (radiotherapy or chemoradiotherapy); GRADE not reported.
2 findings from 1 review
Quality of life · All patients with cancer who are receiving treatment
2 findings from 1 review
Summary of findings 2 (melphalan/HSCT): Quality of life - '1 study assessed this outcome but the data are currently unavailable as the study report and analysis have not yet been completed' (Toro 2013; measured with…
1 study
GRADE not reported
Summary of findings for the main comparison (5FU solid cancers): Quality of life - 'No studies assessed this outcome'.
0 studies
No studies found
Caries development in permanent teeth · People of all ages in a community setting; the included caries studies were all in children aged 3 to 16 years
Initiation of water fluoridation (artificial or natural) may leads to lower caries in permanent teeth (change in DMFT) compared with low/non-fluoridated water (0.4 ppm fluoride or less) (low certainty).
1 finding from 1 review
Adverse events: gingival bleeding · Children with decayed primary molar teeth
Preformed crown (any material; conventional technique or Hall… showed no clear difference in adverse events: gingival bleeding compared with filling (any material; with or without complete carious tissue…; GRADE not reported.
2 findings from 1 review
Satisfaction with treatment · Children with decayed primary molar teeth
The review found no eligible studies for this question.
1 finding from 1 review
Unacceptability of treatment (dropouts/exclusions during the trial) · Children and adolescents aged 16 years or less
Fluoride gel (topically applied; operator- or self-applied; any… showed no clear difference in unacceptability of treatment (dropouts/exclusions during the trial) compared with placebo or no treatment; GRADE not reported.
3 findings from 1 review
Quality of root-end filling (retrograde/surgical treatment) · Patients of any age who received endodontic therapy and were followed up for at least 1 year after treatment
The review found no eligible studies for this question.
1 finding from 1 review
Pacifier withdrawal vs No treatment
Outcome not reported · Children with a non-nutritive sucking habit (digit or pacifier)
The review found no eligible studies for this question.
1 finding from 1 review
Adverse events · All patients with cancer who are receiving treatment
2 findings from 1 review
Adverse events reported narratively: one study did not report adverse events (Askarifar 2015); another reported no serious adverse events (Toro 2013); the remaining two reported low rates of shooting pain from the…
3 studies
GRADE not reported
Adverse events reported narratively (not meta-analysed): one study reported no adverse effects (Katranci 2012); the other four 5FU studies reported low rates of very minor adverse events (headache, chills,…
5 studies · 444 participants
GRADE not reported
Patient satisfaction / quality of life (validated measure) · People with a permanent tooth that has undergone endodontic (root canal) treatment
The review found no eligible studies for this question.
1 finding from 1 review
Oral mucositis (severe) · Patients with osteosarcoma (bone cancer) receiving high-dose methotrexate, vincristine and leucovorin
1 finding from 1 review
Oral mucositis (severe). Not estimable - no participants had developed severe oral mucositis by the fourth day after chemotherapy when the data were reported (Zhang 2011, Analysis 4.3, subgroup 3.1); 118 participants…
1 study · 118 participants
GRADE not reported
Pain · Children with decayed primary molar teeth
Preformed crown (any material; conventional technique or Hall… probably leads to lower pain compared with filling (any material; with or without complete carious tissue… (moderate certainty).
2 findings from 1 review
Adverse effects: dental fluorosis · general population
The review found no eligible studies for this question.
1 finding from 1 review
Caries (lesion) progression (radiographic) · Dentate children and adults with non-cavitated proximal caries lesions extending into enamel or dentine (not pulp) in primary or permanent…
Glass ionomer sealant (with fluoride gel plus dentifrice) showed no clear difference in caries (lesion) progression (radiographic) compared with fluoride gel plus fluoride toothpaste/dentifrice (non-invasive…; GRADE not reported.
1 finding from 1 review
OR 0.13 [0.01, 2.52]
1 study
GRADE not reported
Quality of root-end filling (retrograde/surgical treatment) · Patients of any age who received endodontic therapy and were followed up for at least 1 year after treatment
The review found no eligible studies for this question.
1 finding from 1 review
Adverse effects (loose stools, diarrhoea) · Infants (primary teeth; baseline about 9 to 15 months)
1 finding from 1 review
Adverse effects were not reported in a usable format, but the reported rates of loose stools and diarrhoea were very similar between groups. There were no serious adverse effects during the study. Milgrom 2009.
1 study · 94 participants
GRADE not reported
Change in proportion of caries-free children (deciduous or permanent teeth) · People of all ages in a previously fluoridated community (Maupome 2001: children with generally low caries experience)
The review found no eligible studies for this question.
1 finding from 1 review
Preformed crown (any material; conventional technique or Hall Technique) vs No treatment
Outcome not reported · Children with decayed primary molar teeth
The review found no eligible studies for this question.
1 finding from 1 review
Pain · Children with decayed primary molar teeth
The review found no eligible studies for this question.
1 finding from 1 review
Oral mucositis (moderate to severe) · Adults with solid cancers receiving fluorouracil (5FU) and leucovorin
It is very uncertain whether oral cryotherapy for 30 minutes changes oral mucositis (moderate to severe) compared with oral cryotherapy for 60 minutes (very low certainty).
1 finding from 1 review