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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
1,956 questions in 143 reviews · Musculoskeletal
current versionsNo studies 555 · 28.4%Ungraded 107 · 5.5%Very low 255 · 13%Low 555 · 28.4%Moderate 357 · 18.3%High 127 · 6.5%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Hand exercise vs no exercise Radiographic joint structure changes Not measured · patients with hand osteoarthritis Exercise for hand osteoarthritis (2017) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Hand exercise vs no exercise Quality of life Self‐report questionnaires Scale from 0 to 100 (100 represents maximum quality of life) · patients with hand osteoarthritis Exercise for hand osteoarthritis (2017) · Cochrane | no estimate extracted | 1 study · 113 participants | Very low |
Hand exercise vs no exercise Finger joint stiffness Self‐reported questionnaires Scale from 0 to 10 (0 represents no stiffness). · patients with hand osteoarthritis Exercise for hand osteoarthritis (2017) · Cochrane | no estimate extracted | 4 studies · 368 participants | Low |
Hand exercise vs no exercise Adverse events · patients with hand osteoarthritis Exercise for hand osteoarthritis (2017) · Cochrane | RR 4.55 [0.53, 39.31] | 3 studies · 309 participants | Very low |
Hand exercise vs no exercise Withdrawal due to adverse events · patients with hand osteoarthritis Exercise for hand osteoarthritis (2017) · Cochrane | RR 2.88 [0.3, 27.18] | 3 studies · 309 participants | Very low |
Whole body vibration vs control Health‐related quality of life assessed by FIQ total scale, 0 to 100, 0 is best · individuals with fibromyalgia Whole body vibration exercise training for fibromyalgia (2017) · Cochrane | no estimate extracted | 1 study · 41 participants | Very low |
Whole body vibration plus mixed exercise vs control Fatigue assessed by FIQ scale, 0 to 100 mm, 0 is best · individuals with fibromyalgia Whole body vibration exercise training for fibromyalgia (2017) · Cochrane | no estimate extracted | 1 study · 21 participants | Very low |
Whole body vibration plus mixed exercise vs control Stiffness assessed by FIQ scale, 0 to 100 mm scale, 0 is best · individuals with fibromyalgia Whole body vibration exercise training for fibromyalgia (2017) · Cochrane | no estimate extracted | 1 study · 21 participants | Very low |
Whole body vibration plus mixed exercise vs control Physical function · individuals with fibromyalgia Whole body vibration exercise training for fibromyalgia (2017) · Cochrane | no estimate extracted | NR | No studies |
Whole body vibration plus mixed exercise vs control Adverse events (narrative) · individuals with fibromyalgia Whole body vibration exercise training for fibromyalgia (2017) · Cochrane | no estimate extracted | 2008 participants | Ungraded |
Whole body vibration plus mixed exercise vs control All‐cause withdrawal assessed by number of people who dropped out · individuals with fibromyalgia Whole body vibration exercise training for fibromyalgia (2017) · Cochrane | RR 0.25 | 2 studies · 46 participants | Very low |
Whole body vibration vs control Pain intensity · individuals with fibromyalgia Whole body vibration exercise training for fibromyalgia (2017) · Cochrane | no estimate extracted | NR | No studies |
Whole body vibration vs control Fatigue · individuals with fibromyalgia Whole body vibration exercise training for fibromyalgia (2017) · Cochrane | no estimate extracted | NR | No studies |
Whole body vibration vs control Stiffness · individuals with fibromyalgia Whole body vibration exercise training for fibromyalgia (2017) · Cochrane | no estimate extracted | NR | No studies |
Whole body vibration vs control Physical function · individuals with fibromyalgia Whole body vibration exercise training for fibromyalgia (2017) · Cochrane | no estimate extracted | NR | No studies |
Whole body vibration vs control Adverse events (narrative) · individuals with fibromyalgia Whole body vibration exercise training for fibromyalgia (2017) · Cochrane | no estimate extracted | 1 study · 2010 participants | Ungraded |
Whole body vibration vs control All‐cause withdrawal assessed by number of people who dropped out · individuals with fibromyalgia Whole body vibration exercise training for fibromyalgia (2017) · Cochrane | RR 1.43 [0.27, 7.67] | 1 study · 41 participants | Very low |
Whole body vibration plus mixed exercise vs control Health‐related quality of life assessed by FIQ total scale, 0‐100, 0 is best · individuals with fibromyalgia Whole body vibration exercise training for fibromyalgia (2017) · Cochrane | no estimate extracted | 1 study · 21 participants | Very low |
Whole body vibration plus mixed exercise vs control Pain Intensity assessed by FIQ scale, 0 to 100 mm, 0 is no pain · individuals with fibromyalgia Whole body vibration exercise training for fibromyalgia (2017) · Cochrane | no estimate extracted | 1 study · 21 participants | Very low |
Celecoxib vs placebo Clinical improvement: American College of Rheumatology 20% improvement criteria (ACR20) · people with rheumatoid arthritis Celecoxib for rheumatoid arthritis (2017) · Cochrane | RR 1.53 [1.25, 1.86] | 2 studies · 873 participants | Moderate |
Celecoxib vs traditional NSAIDs Physical function: Health Assessment Questionnaire Disability Index (HAQ) scale 0 to 3; higher scores means worse functional ability; · people with rheumatoid arthritis Celecoxib for rheumatoid arthritis (2017) · Cochrane | no estimate extracted | 2 studies · 849 participants | Low |
Celecoxib vs traditional NSAIDs Cardiovascular events (myocardial infarction, stroke) · people with rheumatoid arthritis Celecoxib for rheumatoid arthritis (2017) · Cochrane | Peto OR 1.13 [0.07, 18.33] | 1 study · 149 participants | Low |
Celecoxib vs traditional NSAIDs Incidence of gastroduodenal ulcers ≥ 3 mm · people with rheumatoid arthritis Celecoxib for rheumatoid arthritis (2017) · Cochrane | RR 0.21 [0.14, 0.32] | 5 studies · 1568 participants | Moderate |
Celecoxib vs traditional NSAIDs Short‐term serious adverse events · people with rheumatoid arthritis Celecoxib for rheumatoid arthritis (2017) · Cochrane | Peto OR 0.71 [0.39, 1.28] | 5 studies · 2154 participants | Low |
Celecoxib vs traditional NSAIDs Total withdrawals; · people with rheumatoid arthritis Celecoxib for rheumatoid arthritis (2017) · Cochrane | RR 0.73 [0.62, 0.86] | 6 studies · 2639 participants | Moderate |
Celecoxib vs placebo Pain: self‐reported visual analogue scale (VAS) from 0 to 100 points (where 0 is no pain) · people with rheumatoid arthritis Celecoxib for rheumatoid arthritis (2017) · Cochrane | no estimate extracted | 1 study · 706 participants | Moderate |
Celecoxib vs placebo Physical function: Health Assessment Questionnaire Disability Index (HAQ) scale 0 to 3; higher scores means worse functional ability; · people with rheumatoid arthritis Celecoxib for rheumatoid arthritis (2017) · Cochrane | no estimate extracted | 1 study · 706 participants | Low |
Celecoxib vs placebo Cardiovascular events (myocardial infarction, stroke) · people with rheumatoid arthritis Celecoxib for rheumatoid arthritis (2017) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Celecoxib vs placebo Incidence of gastroduodenal ulcers ≥ 3 mm · people with rheumatoid arthritis Celecoxib for rheumatoid arthritis (2017) · Cochrane | Peto OR 1.26 [0.44, 3.63] | 1 study · 392 participants | Low |
Celecoxib vs placebo Short‐term serious adverse events · people with rheumatoid arthritis Celecoxib for rheumatoid arthritis (2017) · Cochrane | Peto OR 0.87 [0.28, 2.69] | 1 study · 706 participants | Low |
Celecoxib vs placebo Total withdrawals; · people with rheumatoid arthritis Celecoxib for rheumatoid arthritis (2017) · Cochrane | RR 0.61 [0.52, 0.72] | 1 study · 706 participants | Low |
Celecoxib vs traditional NSAIDs Clinical improvement: American College of Rheumatology 20% improvement criteria (ACR20) · people with rheumatoid arthritis Celecoxib for rheumatoid arthritis (2017) · Cochrane | RR 1.1 [0.99, 1.23] | 4 studies · 1981 participants | Moderate |
Celecoxib vs traditional NSAIDs Pain: self‐reported visual analogue scale (VAS) from 0 to 100 (where 0 is no pain) · people with rheumatoid arthritis Celecoxib for rheumatoid arthritis (2017) · Cochrane | no estimate extracted | 3 studies · 1504 participants | Moderate |
Aerobic exercise training vs control Health‐related quality of life FIQ Total. Scale from 0 to 100 (0 is best) · individuals with fibromyalgia Aerobic exercise training for adults with fibromyalgia (2017) · Cochrane | no estimate extracted | 5 studies · 372 participants | Moderate |
Aerobic exercise training vs control Pain intensity Visual analogue scale Scale from 0 to 100 mm (0 is best) · individuals with fibromyalgia Aerobic exercise training for adults with fibromyalgia (2017) · Cochrane | no estimate extracted | 6 studies · 351 participants | Low |
Aerobic exercise training vs control Fatigue Visual analogue scale Scale from 0 to 100 mm (0 is best) · individuals with fibromyalgia Aerobic exercise training for adults with fibromyalgia (2017) · Cochrane | no estimate extracted | 3 studies · 246 participants | Low |
Aerobic exercise training vs control Stiffness FIQ Scale from 0 to 100 mm (lower scores mean less stiffness) · individuals with fibromyalgia Aerobic exercise training for adults with fibromyalgia (2017) · Cochrane | no estimate extracted | 1 study · 143 participants | Low |
Aerobic exercise training vs control Physical function FIQ and SF‐36 converted, 0 to 100 scale (0 is best) · individuals with fibromyalgia Aerobic exercise training for adults with fibromyalgia (2017) · Cochrane | no estimate extracted | 3 studies · 246 participants | Low |
Aerobic exercise training vs control Withdrawals All‐cause attrition · individuals with fibromyalgia Aerobic exercise training for adults with fibromyalgia (2017) · Cochrane | RR 1.25 [0.89, 1.77] | 8 studies · 456 participants | Moderate |
Aerobic exercise training vs control Adverse events Descriptive information · individuals with fibromyalgia Aerobic exercise training for adults with fibromyalgia (2017) · Cochrane | no estimate extracted | 1996 participants | Ungraded |
Bisphosphonates vs control Incident vertebral fractures Radiographic · adults with GIOP Bisphosphonates for steroid‐induced osteoporosis (2016) · Cochrane | RR 0.57 [0.35, 0.91] | 12 studies · 1343 participants | High |
Bisphosphonates vs control Incident nonvertebral fractures Radiographic · adults with GIOP Bisphosphonates for steroid‐induced osteoporosis (2016) · Cochrane | RR 0.79 [0.47, 1.33] | 9 studies · 1245 participants | Low |
Bisphosphonates vs control Lumbar spine BMD DEXA · adults with GIOP Bisphosphonates for steroid‐induced osteoporosis (2016) · Cochrane | no estimate extracted | 23 studies · 2042 participants | Moderate |
Bisphosphonates vs control Femoral neck BMD DEXA · adults with GIOP Bisphosphonates for steroid‐induced osteoporosis (2016) · Cochrane | no estimate extracted | 18 studies · 1665 participants | Moderate |
Bisphosphonates vs control Serious adverse events · adults with GIOP Bisphosphonates for steroid‐induced osteoporosis (2016) · Cochrane | RR 0.91 [0.74, 1.12] | 15 studies · 1703 participants | Low |
Bisphosphonates vs control Withdrawals due to adverse events · adults with GIOP Bisphosphonates for steroid‐induced osteoporosis (2016) · Cochrane | RR 1.06 [0.77, 1.47] | 15 studies · 1790 participants | Low |
Bisphosphonates vs control Quality of life · adults with GIOP Bisphosphonates for steroid‐induced osteoporosis (2016) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Intervention NR Pain on a 0 to 100 scale. Various pain scales. (lower score is better) Aquatic exercise for the treatment of knee and hip osteoarthritis (2016) · Cochrane | no estimate extracted | 12 studies · 1135 participants | Moderate |
Intervention NR Disability on a 0 to 100 scale. Various disability scales (lower score is better) Aquatic exercise for the treatment of knee and hip osteoarthritis (2016) · Cochrane | no estimate extracted | 12 studies · 1116 participants | Moderate |
Intervention NR Quality of life on a 0 to 100 scale. Various quality of life scales. (higher score is better) Aquatic exercise for the treatment of knee and hip osteoarthritis (2016) · Cochrane | no estimate extracted | 10 studies · 1027 participants | Moderate |