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Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

2,206 questions in 117 reviews · Common Mental Disorders

current versions
No studies 387 · 17.5%Ungraded 111 · 5%Very low 635 · 28.8%Low 568 · 25.7%Moderate 449 · 20.4%High 56 · 2.5%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Intervention NR
Change in hospital admission rates · adults or children of all ethnicities
Means restriction for the prevention of suicide by jumping (2020) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Attempted suicide · adults or children of all ethnicities
Means restriction for the prevention of suicide by jumping (2020) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Cost‐effectiveness of interventions (the study reviewed suicide data from a bridge and surrounding areas over a 70‐year period, and estimated reductions in mortality due to the barrier over a 20‐year period) · adults or children of all ethnicities
Means restriction for the prevention of suicide by jumping (2020) · Cochrane
no estimate extracted1 study · 1 participantsLow
Intervention NR
Suicide (Observation period: pre‐intervention 19.5 years; postintervention 6.5 years) · adults or children of all ethnicities
Means restriction for the prevention of suicide by jumping (2020) · Cochrane
IRR 0.092 studies · 2 participantsLow
Intervention NR
Attempted suicide · adults or children of all ethnicities
Means restriction for the prevention of suicide by jumping (2020) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Study withdrawal · adults or children of all ethnicities
Means restriction for the prevention of suicide by jumping (2020) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Change in hospital admission rates · adults or children of all ethnicities
Means restriction for the prevention of suicide by jumping (2020) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Cost‐effectiveness of interventions · adults or children of all ethnicities
Means restriction for the prevention of suicide by jumping (2020) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Study withdrawal · adults or children of all ethnicities
Means restriction for the prevention of suicide by jumping (2020) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Change in hospital admission rates · adults or children of all ethnicities
Means restriction for the prevention of suicide by jumping (2020) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Cost‐effectiveness of interventions · adults or children of all ethnicities
Means restriction for the prevention of suicide by jumping (2020) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Suicide (Observation period ‐ pre‐intervention: 89 years; postintervention 78.5 years) · adults or children of all ethnicities
Means restriction for the prevention of suicide by jumping (2020) · Cochrane
IRR 0.059 studies · 9 participantsLow
Intervention NR
Attempted suicide · adults or children of all ethnicities
Means restriction for the prevention of suicide by jumping (2020) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Study withdrawal · adults or children of all ethnicities
Means restriction for the prevention of suicide by jumping (2020) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Change in hospital admission rates · adults or children of all ethnicities
Means restriction for the prevention of suicide by jumping (2020) · Cochrane
no estimate extractedNRNo studies
Antidepressants plus benzodiazepines vs antidepressants alone
Depression severity: early phase (2 weeks, range 1–4 weeks) · people with major depression
Antidepressants plus benzodiazepines for adults with major depression (2019) · Cochrane
no estimate extracted10 studies · 598 participantsModerate
Antidepressants plus benzodiazepines vs antidepressants alone
Depression severity: acute phase (8 weeks, range 5–12 weeks) · people with major depression
Antidepressants plus benzodiazepines for adults with major depression (2019) · Cochrane
no estimate extracted7 studies · 347 participantsLow
Antidepressants plus benzodiazepines vs antidepressants alone
Depression severity: continuous phase (> 12 weeks) · people with major depression
Antidepressants plus benzodiazepines for adults with major depression (2019) · Cochrane
no estimate extracted1 study · 50 participantsLow
Antidepressants plus benzodiazepines vs antidepressants alone
Acceptability of treatment (dropout for any reason) · people with major depression
Antidepressants plus benzodiazepines for adults with major depression (2019) · Cochrane
RR 0.76 [0.54, 1.07]10 studies · 731 participantsModerate
Antidepressants plus benzodiazepines vs antidepressants alone
Anxiety severity: early phase (2 weeks, range 1–4 weeks) · people with major depression
Antidepressants plus benzodiazepines for adults with major depression (2019) · Cochrane
no estimate extracted3 studies · 129 participantsVery low
Antidepressants plus benzodiazepines vs antidepressants alone
Adverse effects (dropouts) · people with major depression
Antidepressants plus benzodiazepines for adults with major depression (2019) · Cochrane
RR 0.54 [0.32, 0.9]10 studies · 731 participantsModerate
Exercise therapy vs control
FatigueMeasured at end of treatment (12‐26 weeks) · men and women aged over 18 years with chronic fatigue syndrome
Exercise therapy for chronic fatigue syndrome (2019) · Cochrane
no estimate extracted7 studies · 840 participantsModerate
Exercise therapy vs control
Depression Measured at end of treatment; 12‐26 weeks · men and women aged over 18 years with chronic fatigue syndrome
Exercise therapy for chronic fatigue syndrome (2019) · Cochrane
no estimate extracted5 studies · 504 participantsVery low
Exercise therapy vs control
Depression Measured after 52‐70 weeks · men and women aged over 18 years with chronic fatigue syndrome
Exercise therapy for chronic fatigue syndrome (2019) · Cochrane
no estimate extracted4 studies · 654 participantsVery low
Exercise therapy vs control
Sleep Measured at end of treatment, 12‐26 weeks · men and women aged over 18 years with chronic fatigue syndrome
Exercise therapy for chronic fatigue syndrome (2019) · Cochrane
no estimate extracted2 studies · 323 participantsLow
Exercise therapy vs control
Sleep Measured after 52‐70 weeks · men and women aged over 18 years with chronic fatigue syndrome
Exercise therapy for chronic fatigue syndrome (2019) · Cochrane
no estimate extracted3 studies · 610 participantsLow
Exercise therapy vs psychological treatment
Fatigue Measured at end of treatment, 24 weeks · men and women aged over 18 years with chronic fatigue syndrome
Exercise therapy for chronic fatigue syndrome (2019) · Cochrane
no estimate extracted1 study · 298 participantsLow
Exercise therapy vs psychological treatment
Fatigue Measured after 52 weeks · men and women aged over 18 years with chronic fatigue syndrome
Exercise therapy for chronic fatigue syndrome (2019) · Cochrane
no estimate extracted2 studies · 351 participantsModerate
Exercise therapy vs psychological treatment
Participants with serious adverse reactions Measured after 52 weeks Measured according to European Union Clinical Trials Directive by recording the number of serious reactions · men and women aged over 18 years with chronic fatigue syndrome
Exercise therapy for chronic fatigue syndrome (2019) · Cochrane
RR 0.67 [0.11, 3.96]1 study · 321 participantsVery low
Exercise therapy vs psychological treatment
Pain intensity End of treatment · men and women aged over 18 years with chronic fatigue syndrome
Exercise therapy for chronic fatigue syndrome (2019) · Cochrane
no estimate extractedNRNo studies
Exercise therapy vs psychological treatment
Pain intensity Measured after 52 weeks · men and women aged over 18 years with chronic fatigue syndrome
Exercise therapy for chronic fatigue syndrome (2019) · Cochrane
no estimate extracted1 study · 43 participantsVery low
Exercise therapy vs psychological treatment
Physical functioning Measured at end of treatment, 24 weeks · men and women aged over 18 years with chronic fatigue syndrome
Exercise therapy for chronic fatigue syndrome (2019) · Cochrane
no estimate extracted1 study · 298 participantsLow
Exercise therapy vs control
FatigueMeasured after 52‐70 weeks · men and women aged over 18 years with chronic fatigue syndrome
Exercise therapy for chronic fatigue syndrome (2019) · Cochrane
no estimate extracted4 studies · 670 participantsVery low
Exercise therapy vs psychological treatment
Physical functioning Measured after 52 weeks · men and women aged over 18 years with chronic fatigue syndrome
Exercise therapy for chronic fatigue syndrome (2019) · Cochrane
no estimate extracted2 studies · 348 participantsVery low
Exercise therapy vs psychological treatment
Quality of Life (QoL) · men and women aged over 18 years with chronic fatigue syndrome
Exercise therapy for chronic fatigue syndrome (2019) · Cochrane
no estimate extractedNRNo studies
Exercise therapy vs psychological treatment
Quality of Life (QoL) Measured after 52 weeks Measured on the Quality of Life Scale, 16‐112 points High score means better quality of life · men and women aged over 18 years with chronic fatigue syndrome
Exercise therapy for chronic fatigue syndrome (2019) · Cochrane
no estimate extracted1 study · 44 participantsVery low
Exercise therapy vs psychological treatment
Depression · men and women aged over 18 years with chronic fatigue syndrome
Exercise therapy for chronic fatigue syndrome (2019) · Cochrane
no estimate extractedNRNo studies
Exercise therapy vs psychological treatment
Depression Measured after 52 weeks HADS depression score (0‐21 points) or Beck Depression Inventory‐II (0‐63 points) Low score means fewer symptoms · men and women aged over 18 years with chronic fatigue syndrome
Exercise therapy for chronic fatigue syndrome (2019) · Cochrane
no estimate extracted2 studies · 331 participantsModerate
Exercise therapy vs psychological treatment
Sleep · men and women aged over 18 years with chronic fatigue syndrome
Exercise therapy for chronic fatigue syndrome (2019) · Cochrane
no estimate extractedNRNo studies
Exercise therapy vs psychological treatment
Sleep Measured after 52 weeks Jenkins Sleep Scale, 0‐20 points Low score means better sleep · men and women aged over 18 years with chronic fatigue syndrome
Exercise therapy for chronic fatigue syndrome (2019) · Cochrane
no estimate extracted1 study · 287 participantsLow
Exercise therapy vs adaptive pacing therapy
Fatigue Measured at end of treatment, 24 weeks · men and women aged over 18 years with chronic fatigue syndrome
Exercise therapy for chronic fatigue syndrome (2019) · Cochrane
no estimate extracted1 study · 305 participantsLow
Exercise therapy vs adaptive pacing therapy
Fatigue Measured at end of treatment, 52 weeks · men and women aged over 18 years with chronic fatigue syndrome
Exercise therapy for chronic fatigue syndrome (2019) · Cochrane
no estimate extracted1 study · 307 participantsLow
Exercise therapy vs adaptive pacing therapy
Participants with serious adverse reactions Measured after 52 weeks Measured according to European Union Clinical Trials Directive by recording the number of serious reactions · men and women aged over 18 years with chronic fatigue syndrome
Exercise therapy for chronic fatigue syndrome (2019) · Cochrane
RR 0.99 [0.14, 6.97]1 study · 319 participantsVery low
Exercise therapy vs control
Participants with serious adverse reactions Measured after 52 weeks Measured according to European Union Clinical Trials Directive by recording the number of serious reactions · men and women aged over 18 years with chronic fatigue syndrome
Exercise therapy for chronic fatigue syndrome (2019) · Cochrane
RR 0.99 [0.14, 6.97]1 study · 319 participantsVery low
Exercise therapy vs adaptive pacing therapy
Pain End of treatment and long term · men and women aged over 18 years with chronic fatigue syndrome
Exercise therapy for chronic fatigue syndrome (2019) · Cochrane
no estimate extractedNRNo studies
Exercise therapy vs adaptive pacing therapy
Physical functioning Measured at end of treatment, 24 weeks · men and women aged over 18 years with chronic fatigue syndrome
Exercise therapy for chronic fatigue syndrome (2019) · Cochrane
no estimate extracted1 study · 305 participantsLow
Exercise therapy vs adaptive pacing therapy
Physical functioning Measured at end of treatment, 52 weeks · men and women aged over 18 years with chronic fatigue syndrome
Exercise therapy for chronic fatigue syndrome (2019) · Cochrane
no estimate extracted1 study · 307 participantsLow
Exercise therapy vs adaptive pacing therapy
Quality of Life (QOL) End of treatment and long term · men and women aged over 18 years with chronic fatigue syndrome
Exercise therapy for chronic fatigue syndrome (2019) · Cochrane
no estimate extractedNRNo studies
Exercise therapy vs adaptive pacing therapy
Depression Measured at end of treatment · men and women aged over 18 years with chronic fatigue syndrome
Exercise therapy for chronic fatigue syndrome (2019) · Cochrane
no estimate extractedNRNo studies
Exercise therapy vs adaptive pacing therapy
Depression Measured after 52 weeks HADS depression score, 0‐21 points Low score means fewer symptoms · men and women aged over 18 years with chronic fatigue syndrome
Exercise therapy for chronic fatigue syndrome (2019) · Cochrane
no estimate extracted1 study · 293 participantsLow