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Evidence found and GRADE certainty

383 questions · 414 findings · 46 reviews · Hypertension

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No studies found 15 · 3.6%GRADE not reported 31 · 7.5%Very low 80 · 19.3%Low 148 · 35.7%Moderate 116 · 28%High 24 · 5.8%

Intervention not reported

Mortality 4 to 5 years · Adults with mild hypertension and no cardiovascular disease

It is very uncertain whether the intervention changes mortality 4 to 5 years (very low certainty).

1 finding from 1 review

Intervention not reported

Total CV events 5 years · Adults with mild hypertension and no cardiovascular disease

It is very uncertain whether the intervention changes total CV events 5 years (very low certainty).

1 finding from 1 review

Intervention not reported

Withdrawals due to adverse effects 5 years · Adults with mild hypertension and no cardiovascular disease

The intervention probably leads to higher withdrawals due to adverse effects 5 years (moderate certainty).

1 finding from 1 review

Intensive periodontal treatment (subgingival SRP with or without other periodontal treatment) vs No treatment (no periodontal treatment)

Diastolic blood pressure (mmHg), change from baseline · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension

Periodontal treatment (subgingival SRP with or without other… showed no clear difference in change in diastolic blood pressure (DBP, mmHg) compared with no treatment (no periodontal treatment) (low certainty).

4 findings from 1 review
Show 1 more finding
  • Effect of periodontal treatments on blood pressure 2021 · Cochrane All outcomes
    Long term (follow-up 6 months) · People diagnosed with periodontitis and other cardiovascular diseases except hypertension
    MD -2.55 [-6.9, 1.8]
    2 studies · 103 participants
    Low

Intensive periodontal treatment (subgingival SRP with or without other periodontal treatment) vs No treatment (no periodontal treatment)

Clinical attachment level (CAL) · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension

Periodontal treatment (subgingival SRP with or without other… led to lower clinical attachment level (CAL) compared with no treatment (no periodontal treatment); GRADE not reported.

1 finding from 1 review

Intensive periodontal treatment (subgingival SRP with or without other periodontal treatment) vs No treatment (no periodontal treatment)

Systolic blood pressure (mmHg), change from baseline · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension

Periodontal treatment (subgingival SRP with or without other… showed no clear difference in change in systolic blood pressure (SBP, mmHg) compared with no treatment (no periodontal treatment) (low certainty).

4 findings from 1 review
Show 1 more finding
  • Effect of periodontal treatments on blood pressure 2021 · Cochrane All outcomes
    Short term (follow-up 3 months) · People diagnosed with periodontitis and other cardiovascular diseases except hypertension
    MD 0.59 [-9.18, 10.36]
    1 study · 55 participants
    Very low

Intensive periodontal treatment (subgingival SRP with or without other periodontal treatment) vs No treatment (no periodontal treatment)

Probing pocket depth · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension

Periodontal treatment (subgingival SRP with or without other… led to lower pocket probing depth (PPD) compared with no treatment (no periodontal treatment); GRADE not reported.

1 finding from 1 review

Intensive periodontal treatment (subgingival SRP with or without other periodontal treatment) vs No treatment (no periodontal treatment)

Plasma level of hs-CRP (mg/L) · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension

Periodontal treatment (subgingival SRP with or without other… showed no clear difference in plasma level of hs-CRP (mg/L) compared with no treatment (no periodontal treatment); GRADE not reported.

4 findings from 1 review
Show 1 more finding

Intensive periodontal treatment (subgingival SRP with or without other periodontal treatment) vs No treatment (no periodontal treatment)

Adverse events (participants with adverse events or withdrawals due to adverse events) · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension
1 finding from 1 review
  • Effect of periodontal treatments on blood pressure 2021 · Cochrane All outcomes
    SoF 1 (Adverse effects): Only 1 study reported that 1 participant in the treatment group experienced a myocardial infarction during the study period. 1 study reported no adverse effects. The remaining 2 studies did not…
    2 studies · 294 participants
    Low

Intensive periodontal treatment (subgingival SRP with or without other periodontal treatment) vs No treatment (no periodontal treatment)

Endothelial function · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension

Periodontal treatment (subgingival SRP with or without other… showed no clear difference in endothelial function (forearm blood flow) compared with no treatment (no periodontal treatment); GRADE not reported.

1 finding from 1 review

Intensive periodontal treatment (subgingival SRP with or without other periodontal treatment) vs No treatment (no periodontal treatment)

Plasma level of IL-6 (pg/mL) · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension

Periodontal treatment (subgingival SRP with or without other… showed no clear difference in plasma level of IL-6 (pg/mL) compared with no treatment (no periodontal treatment); GRADE not reported.

3 findings from 1 review

Intensive periodontal treatment (subgingival SRP with or without other periodontal treatment) vs No treatment (no periodontal treatment)

Percentage of bleeding on probing (BOP) · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension

Periodontal treatment (subgingival SRP with or without other… led to lower bleeding on probing (BOP) compared with no treatment (no periodontal treatment); GRADE not reported.

1 finding from 1 review
  • Effect of periodontal treatments on blood pressure 2021 · Cochrane All outcomes
    Long term · People diagnosed with periodontitis and other cardiovascular diseases except hypertension
    MD -36.80 [-46.47, -27.13]
    1 study · 48 participants
    GRADE not reported

Intensive periodontal treatment (subgingival SRP with or without other periodontal treatment) vs No treatment (no periodontal treatment)

Heart rate · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension

Periodontal treatment (subgingival SRP with or without other… showed no clear difference in heart rate compared with no treatment (no periodontal treatment); GRADE not reported.

1 finding from 1 review

Intervention not reported

Systolic blood pressure clinical digital sphygmomanometer · adults with or without hypertension
1 finding from 1 review

Intervention not reported

Diastolic blood pressure clinical digital sphygmomanometer · adults with or without hypertension
1 finding from 1 review

Intervention not reported

Withdrawals due to adverse effects · adults with or without hypertension
1 finding from 1 review