Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

592 questions · 604 findings · 53 reviews · Headline outcomes only

No studies found 151 · 25%GRADE not reported 31 · 5.1%Very low 94 · 15.6%Low 170 · 28.1%Moderate 114 · 18.9%High 44 · 7.3%

Dietary modifications (counselling or dietary change) vs no nutritional intervention

Diarrhoea · People undergoing RT for pelvic cancer

Dietary modification probably leads to lower diarrhoea at end of treatment compared with no nutritional intervention (moderate certainty).

1 finding from 1 review

Intervention not reported

Supportive care only*** (1 RCT, 81 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40); radiotherapy with 60 Gy in…
1 finding from 1 review

Intervention not reported

TMZ (3 RCTs, 538 participants) · elderly people with newly diagnosed glioblastoma Interventions: chemoradiotherapy (CRT); chemoradiotherapy plus bevacizumab (BEV_CRT);…

The intervention showed no clear difference in TMZ (3 RCTs, 538 participants) (low certainty).

1 finding from 1 review

Intervention not reported

CRT (2 RCTs; 635 participants) · elderly people with newly diagnosed glioblastoma Interventions: chemoradiotherapy (CRT); chemoradiotherapy plus bevacizumab (BEV_CRT);…

The intervention leads to lower CRT (2 RCTs; 635 participants) (high certainty).

1 finding from 1 review

Intervention not reported

BEV_CRT (1 RCT; 73 participants) · elderly people with newly diagnosed glioblastoma Interventions: chemoradiotherapy (CRT); chemoradiotherapy plus bevacizumab (BEV_CRT);…

The intervention probably leads to lower BEV_CRT (1 RCT; 73 participants) (moderate certainty).

1 finding from 1 review

Intervention not reported

RT 40 (4 RCTs; 930 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…

The intervention showed no clear difference in RT 40 (4 RCTs; 930 participants) (low certainty).

1 finding from 1 review

Intervention not reported

BEV_RT (1 RCT; 75 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…

It is very uncertain whether the intervention changes BEV_RT (1 RCT; 75 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

TMZ (3 RCTs, 538 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…

It is very uncertain whether the intervention changes TMZ (3 RCTs, 538 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

CRT (2 RCTs; 635 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…

The intervention may leads to lower CRT (2 RCTs; 635 participants) (low certainty).

1 finding from 1 review

Intervention not reported

BEV_CRT (1 RCT; 73 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT 40); chemoradiotherapy (CRT);…

The intervention led to lower BEV_CRT (1 RCT; 73 participants); GRADE not reported.

1 finding from 1 review