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What do systematic reviews say?

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Evidence found and GRADE certainty

805 questions · 838 findings · 55 reviews · Wounds

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No studies found 354 · 42.2%GRADE not reported 38 · 4.5%Very low 283 · 33.8%Low 132 · 15.8%Moderate 27 · 3.2%High 4 · 0.5%

Summary of findings table ‐ Collagen vs standard diet or placebo

Adverse effects/events: at least 1 adverse effect ‐ as defined by individual studies. · adults with pressure ulcers

It is very uncertain whether summary of findings table ‐ Collagen changes side effects: at least one adverse event compared with standard diet or placebo (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Energy, protein and micronutrients vs standard diet

Health‐related quality of life ‐ not reported · inpatients who are mildly or seriously malnourished or at risk of being malnourished, elderly patients at risk of developing pressure ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Psychological interventions vs usual care

Proportion of wounds healed · adults with diabetes with current or previous foot ulceration

It is very uncertain whether psychological intervention changes proportion of wounds completely healed at 3 months compared with standard care (very low certainty).

2 findings from 1 review