Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

628 questions · 651 findings · 39 reviews · Skin

No studies found 167 · 25.7%GRADE not reported 47 · 7.2%Very low 80 · 12.3%Low 139 · 21.4%Moderate 174 · 26.7%High 44 · 6.8%

Itraconazole (200 mg for 6 to 8 weeks) vs placebo

Adverse effects Mild abdominal pain and nausea Adverse effects Mild abnormal liver function · patients with Old World cutaneous leishmaniasis

It is very uncertain whether itraconazole (200 mg for 6 to 8 weeks) changes adverse effects Mild abdominal pain and nausea Adverse effects Mild… compared with placebo (very low certainty).

1 finding from 1 review

Itraconazole (200 mg for 6 to 8 weeks) vs placebo

Microbiological or histopathological cure of skin lesions · patients with Old World cutaneous leishmaniasis

It is very uncertain whether itraconazole (200 mg for 6 to 8 weeks) changes microbiological or histopathological cure of skin lesions compared with placebo (very low certainty).

1 finding from 1 review