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Evidence found and GRADE certainty

480 questions · 484 findings · 52 reviews · Musculoskeletal

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No studies found 114 · 23.6%GRADE not reported 24 · 5%Very low 33 · 6.8%Low 145 · 30%Moderate 116 · 24%High 52 · 10.7%

Diacerein vs placebo

Radiographic progression—minimum joint space width (decreased over 0.50 mm during the study period) · patients with osteoarthritis

Diacerein may leads to lower radiographic progression—minimum joint space width (decreased over… compared with placebo (low certainty).

1 finding from 1 review

Diacerein vs placebo

Quality of life Not measured · patients with osteoarthritis

The review found no eligible studies for this question.

1 finding from 1 review

Diacerein vs placebo

Diarrhoea · patients with osteoarthritis

Diacerein may leads to higher adverse event: diarrhoea compared with placebo (low certainty).

1 finding from 1 review

Diacerein vs placebo

Withdrawals due to adverse events · patients with osteoarthritis

Diacerein showed no clear difference in withdrawal due to adverse events compared with placebo (low certainty).

1 finding from 1 review

Diacerein vs placebo

Total number of serious adverse events not measured · patients with osteoarthritis

The review found no eligible studies for this question.

1 finding from 1 review

Allopurinol vs placebo

Acute gout attacks · people with chronic gout

Allopurinol showed no clear difference in acute gout attacks compared with placebo (moderate certainty).

1 finding from 1 review

Allopurinol vs placebo

Proportion achieving target serum urate · people with chronic gout

Allopurinol probably leads to higher proportion achieving target serum urate compared with placebo (moderate certainty).

1 finding from 1 review

Allopurinol vs placebo

Function · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Allopurinol vs placebo

Tophus regression · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Allopurinol vs placebo

Withdrawals due to adverse events · people with chronic gout

Allopurinol showed no clear difference in withdrawal due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Allopurinol vs placebo

Serious adverse events · people with chronic gout

Allopurinol showed no clear difference in serious adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Pulsed electromagnetic field therapy (PEMF) vs placebo

Function Total recovery of joint function · patients with adhesive capsulitis (frozen shoulder)

It is very uncertain whether pulsed electromagnetic field therapy (PEMF) changes function Total recovery of joint function compared with placebo (very low certainty).

1 finding from 1 review