What do systematic reviews say?

Summary of findings table ‐ Stem Cell vs placebo or control

Summary of findings table ‐ Stem Cell may leads to higher fistula Closure short‐term compared with placebo or Control (low certainty).

• Stem cell transplantation for induction of remission in medically refractory Crohn’s disease 2022 · Cochrane Headline outcomes only
  RR 1.48 [1.12, 1.96]
  4 studies · 269 participants
  Low

Summary of findings table ‐ Stem Cell vs placebo or control

Summary of findings table ‐ Stem Cell may leads to higher fistula closure in long‐term compared with placebo or Control (low certainty).

• Stem cell transplantation for induction of remission in medically refractory Crohn’s disease 2022 · Cochrane Headline outcomes only
  RR 1.42 [1.09, 1.87]
  4 studies · 250 participants
  Low

Summary of findings table ‐ Stem Cell vs placebo or control

It is very uncertain whether summary of findings table ‐ Stem Cell changes total Adverse Events compared with placebo or Control (very low certainty).

• Stem cell transplantation for induction of remission in medically refractory Crohn’s disease 2022 · Cochrane Headline outcomes only
  RR 0.99 [0.88, 1.13]
  4 studies · 293 participants
  Very low

Summary of findings table ‐ Stem Cell vs placebo or control

Summary of findings table ‐ Stem Cell showed no clear difference in serious Adverse Events compared with placebo or Control (low certainty).

• Stem cell transplantation for induction of remission in medically refractory Crohn’s disease 2022 · Cochrane Headline outcomes only
  RR 1.22 [0.88, 1.67]
  7 studies · 433 participants
  Low

Summary of findings table ‐ Stem Cell vs placebo or control

It is very uncertain whether summary of findings table ‐ Stem Cell changes withdrawal due to adverse events compared with placebo or Control (very low certainty).

• Stem cell transplantation for induction of remission in medically refractory Crohn’s disease 2022 · Cochrane Headline outcomes only
  RR 0.78 [0.32, 1.89]
  3 studies · 272 participants
  Very low

Summary of findings table ‐ Ibuprofen 1600 mg vs paracetamol

• Pain management for medical abortion before 14 weeks’ gestation 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 108 participants
  Moderate

Pregabalin 300 mg vs placebo

• Pain management for medical abortion before 14 weeks’ gestation 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 107 participants
  Low

Pregabalin 300 mg vs placebo

Summary of findings table ‐ Pregabalin 300 mg showed no clear difference in gastrointestinal side effects (nausea) compared with placebo (low certainty).

• Pain management for medical abortion before 14 weeks’ gestation 2022 · Cochrane Headline outcomes only
  OR 0.85 [0.33, 2.19]
  1 study · 107 participants
  Low

Pregabalin 300 mg vs placebo

Summary of findings table ‐ Pregabalin 300 mg showed no clear difference in gastrointestinal side effects (vomiting) compared with placebo (low certainty).

• Pain management for medical abortion before 14 weeks’ gestation 2022 · Cochrane Headline outcomes only
  OR 0.76 [0.35, 1.63]
  1 study · 107 participants
  Low

Pregabalin 300 mg vs placebo

Summary of findings table ‐ Pregabalin 300 mg showed no clear difference in gastrointestinal side effects (diarrhoea) compared with placebo (low certainty).

• Pain management for medical abortion before 14 weeks’ gestation 2022 · Cochrane Headline outcomes only
  OR 0.82 [0.38, 1.76]
  1 study · 107 participants
  Low

Pregabalin 300 mg vs placebo

The review found no eligible studies for this question.

• Pain management for medical abortion before 14 weeks’ gestation 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Pregabalin 300 mg vs placebo

The review found no eligible studies for this question.

• Pain management for medical abortion before 14 weeks’ gestation 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Pregabalin 300 mg vs placebo

The review found no eligible studies for this question.

• Pain management for medical abortion before 14 weeks’ gestation 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Pregabalin 300 mg vs placebo

Summary of findings table ‐ Pregabalin 300 mg showed no clear difference in patient satisfaction with analgesia compared with placebo (low certainty).

• Pain management for medical abortion before 14 weeks’ gestation 2022 · Cochrane Headline outcomes only
  OR 0.97 [0.42, 2.21]
  1 study · 104 participants
  Low

Pregabalin 300 mg vs placebo

Summary of findings table ‐ Pregabalin 300 mg showed no clear difference in patient satisfaction with abortion care overall compared with placebo (low certainty).

• Pain management for medical abortion before 14 weeks’ gestation 2022 · Cochrane Headline outcomes only
  OR 1.84 [0.8, 4.22]
  1 study · 105 participants
  Low

Summary of findings table ‐ Ibuprofen 800 mg vs placebo

• Pain management for medical abortion before 14 weeks’ gestation 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 61 participants
  Low

Summary of findings table ‐ Ibuprofen 1600 mg vs paracetamol

The review found no eligible studies for this question.

• Pain management for medical abortion before 14 weeks’ gestation 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings table ‐ Ibuprofen 800 mg vs placebo

Summary of findings table ‐ Ibuprofen 800 mg showed no clear difference in gastrointestinal side effects (nausea) compared with placebo (low certainty).

• Pain management for medical abortion before 14 weeks’ gestation 2022 · Cochrane Headline outcomes only
  OR 1.52 [0.53, 4.37]
  1 study · 61 participants
  Low

Summary of findings table ‐ Ibuprofen 800 mg vs placebo

Summary of findings table ‐ Ibuprofen 800 mg may leads to lower gastrointestinal side effects (vomiting) compared with placebo (low certainty).

• Pain management for medical abortion before 14 weeks’ gestation 2022 · Cochrane Headline outcomes only
  OR 0.19 [0.04, 0.97]
  1 study · 61 participants
  Low

Summary of findings table ‐ Ibuprofen 800 mg vs placebo

The review found no eligible studies for this question.

• Pain management for medical abortion before 14 weeks’ gestation 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found