What do systematic reviews say?

Low molecular weight heparin vs unfractionated heparin

Low molecular weight heparin showed no clear difference in complication and adverse reactions ‐ wound bleeding (analysed by… compared with unfractionated heparin (low certainty).

• Low molecular weight heparin for prevention of microvascular occlusion in digital replantation 2020 · Cochrane Headline outcomes only
  RR 0.53 [0.23, 1.23]
  2 studies · 130 participants
  Low

Low dialysate [Na+] (< 138 mM) vs neutral dialysate [Na+] (138 to 140 mM) or high dialysate [Na+] (> 140 mM)

• Low dialysate sodium levels for chronic haemodialysis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  10 studies · 352 participants
  High

Low dialysate [Na+] (< 138 mM) vs neutral dialysate [Na+] (138 to 140 mM)

• Low dialysate sodium levels for chronic haemodialysis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 112 participants
  Low

Low dialysate [Na+] (< 138 mM) vs neutral dialysate [Na+] (138 to 140 mM)

• Low dialysate sodium levels for chronic haemodialysis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 112 participants
  Low

Low dialysate [Na+] (< 138 mM) vs neutral dialysate [Na+] (138 to 140 mM)

• Low dialysate sodium levels for chronic haemodialysis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 103 participants
  Low

Low dialysate [Na+] (< 138 mM) vs neutral dialysate [Na+] (138 to 140 mM)

• Low dialysate sodium levels for chronic haemodialysis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 169 participants
  Moderate

Low dialysate [Na+] (< 138 mM) vs neutral dialysate [Na+] (138 to 140 mM)

Low dialysate [Na+] (< 138 mM) showed no clear difference in intradialytic cramps compared with neutral dialysate [Na+] (138 to 140 mM) (low certainty).

• Low dialysate sodium levels for chronic haemodialysis 2019 · Cochrane Headline outcomes only
  RR 1.66 [0.92, 2.98]
  4 studies · 11700 participants
  Low

Low dialysate [Na+] (< 138 mM) vs high dialysate [Na+] (> 140 mM)

• Low dialysate sodium levels for chronic haemodialysis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 89 participants
  Moderate

Low dialysate [Na+] (< 138 mM) vs high dialysate [Na+] (> 140 mM)

Low dialysate [Na+] (< 138 mM) showed no clear difference in intradialytic hypotension compared with high dialysate [Na+] (> 140 mM) (low certainty).

• Low dialysate sodium levels for chronic haemodialysis 2019 · Cochrane Headline outcomes only
  RR 1.71 [0.57, 5.07]
  2 studies · 486 participants
  Low

Low dialysate [Na+] (< 138 mM) vs high dialysate [Na+] (> 140 mM)

• Low dialysate sodium levels for chronic haemodialysis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 44 participants
  Low

Low dialysate [Na+] (< 138 mM) vs high dialysate [Na+] (> 140 mM)

• Low dialysate sodium levels for chronic haemodialysis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 38 participants
  Low

Low dialysate [Na+] (< 138 mM) vs high dialysate [Na+] (> 140 mM)

The review found no eligible studies for this question.

• Low dialysate sodium levels for chronic haemodialysis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Low dialysate [Na+] (< 138 mM) vs neutral dialysate [Na+] (138 to 140 mM) or high dialysate [Na+] (> 140 mM)

Low dialysate [Na+] (< 138 mM) probably leads to higher intradialytic hypotension compared with neutral dialysate [Na+] (138 to 140 mM) or high dialysate [Na+] (>… (moderate certainty).

• Low dialysate sodium levels for chronic haemodialysis 2019 · Cochrane Headline outcomes only
  RR 1.52 [1.14, 2.02]
  7 studies · 12570 participants
  Moderate

Low dialysate [Na+] (< 138 mM) vs high dialysate [Na+] (> 140 mM)

• Low dialysate sodium levels for chronic haemodialysis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 89 participants
  Moderate

Low dialysate [Na+] (< 138 mM) vs high dialysate [Na+] (> 140 mM)

Low dialysate [Na+] (< 138 mM) may leads to higher intradialytic cramps compared with high dialysate [Na+] (> 140 mM) (low certainty).

• Low dialysate sodium levels for chronic haemodialysis 2019 · Cochrane Headline outcomes only
  RR 1.94 [1.54, 2.44]
  2 studies · 486 participants
  Low

Low dialysate [Na+] (< 138 mM) vs neutral dialysate [Na+] (138 to 140 mM) or high dialysate [Na+] (> 140 mM)

• Low dialysate sodium levels for chronic haemodialysis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 156 participants
  Moderate

Low dialysate [Na+] (< 138 mM) vs neutral dialysate [Na+] (138 to 140 mM) or high dialysate [Na+] (> 140 mM)

• Low dialysate sodium levels for chronic haemodialysis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 150 participants
  Moderate

Low dialysate [Na+] (< 138 mM) vs neutral dialysate [Na+] (138 to 140 mM) or high dialysate [Na+] (> 140 mM)

• Low dialysate sodium levels for chronic haemodialysis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 103 participants
  Low

Low dialysate [Na+] (< 138 mM) vs neutral dialysate [Na+] (138 to 140 mM) or high dialysate [Na+] (> 140 mM)

• Low dialysate sodium levels for chronic haemodialysis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 258 participants
  Moderate

Low dialysate [Na+] (< 138 mM) vs neutral dialysate [Na+] (138 to 140 mM) or high dialysate [Na+] (> 140 mM)

Low dialysate [Na+] (< 138 mM) probably leads to higher intradialytic cramps compared with neutral dialysate [Na+] (138 to 140 mM) or high dialysate [Na+] (>… (moderate certainty).

• Low dialysate sodium levels for chronic haemodialysis 2019 · Cochrane Headline outcomes only
  RR 1.77 [1.15, 2.73]
  6 studies · 12186 participants
  Moderate