Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,133 questions · 1,153 findings · 36 reviews · Skin

No studies found 407 · 35.3%GRADE not reported 90 · 7.8%Very low 183 · 15.9%Low 209 · 18.1%Moderate 211 · 18.3%High 53 · 4.6%

Mohs micrographic surgery vs surgical excision

Recurrence · adults with basal cell carcinoma of the skin

Mohs micrographic surgery showed no clear difference in recurrence at 3 years compared with surgical excision (low certainty).

2 findings from 1 review

Radiotherapy vs surgical excision

Recurrence · adults with basal cell carcinoma of the skin

Radiotherapy may leads to higher recurrence at 3 years compared with surgical excision (with or without frozen section margin control) (low certainty).

2 findings from 1 review

Radiotherapy vs surgical excision

Cosmetic outcome (good/excellent) · adults with basal cell carcinoma of the skin

Radiotherapy probably leads to lower cosmetic outcome (good/excellent) compared with surgical excision (with or without frozen section margin control) (moderate certainty).

1 finding from 1 review

Imiquimod vs MAL‐PDT

Recurrence · adults with basal cell carcinoma of the skin

Imiquimod cream probably leads to lower recurrence at 3 years compared with MAL‐PDT (moderate certainty).

2 findings from 1 review

Imiquimod vs MAL‐PDT

Cosmesis · adults with basal cell carcinoma of the skin

Imiquimod cream showed no clear difference in cosmetic outcome (excellent/good) compared with MAL‐PDT (moderate certainty).

1 finding from 1 review

Imiquimod vs MAL‐PDT

Number of patients with moderate/severe pain (1 hour postoperatively) · adults with basal cell carcinoma of the skin

Imiquimod cream probably leads to lower pain (moderate/severe) compared with MAL‐PDT (moderate certainty).

1 finding from 1 review

Imiquimod vs MAL‐PDT

Early treatment failure · adults with basal cell carcinoma of the skin

Imiquimod cream showed no clear difference in early treatment failure compared with MAL‐PDT (moderate certainty).

1 finding from 1 review