Proportion of participants developing new or progressive SCI lesions · prevention of SCI in people with SCD who had a stroke (secondary prevention)
It is very uncertain whether hydroxyurea changes proportion of participants developing new or progressive SCI lesions compared with RBC transfusion (very low certainty).
1 finding from 1 review
All‐cause mortality · prevention of SCI in people with SCD who had a stroke (secondary prevention)
It is very uncertain whether hydroxyurea changes all‐cause mortality compared with RBC transfusion (very low certainty).
1 finding from 1 review
SCD ‐ related SAEs ‐ ACS · prevention of SCI in people with SCD who had a stroke (secondary prevention)
It is very uncertain whether hydroxyurea changes SCD‐related SAEs ‐ ACS compared with RBC transfusion (very low certainty).
1 finding from 1 review
SCD‐related SAEs ‐ pain crisis · prevention of SCI in people with SCD who had a stroke (secondary prevention)
Hydroxyurea may leads to higher SCD‐related SAEs ‐ pain crisis compared with RBC transfusion (low certainty).
1 finding from 1 review
Stroke · prevention of SCI in people with SCD who had a stroke (secondary prevention)
It is very uncertain whether hydroxyurea changes clinical stroke compared with RBC transfusion (very low certainty).
1 finding from 1 review
Cognitive function ‐ not reported · prevention of SCI in people with SCD who had a stroke (secondary prevention)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Quality of life ‐ not reported · prevention of SCI in people with SCD who had a stroke (secondary prevention)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
SCD‐related SAEs ‐ pain crisis · prevention of SCI in people with SCD and normal TCD velocities
Long‐term RBC transfusion may leads to lower SCD‐related SAEs ‐ pain crisis compared with standard care (low certainty).
1 finding from 1 review
Stroke · prevention of SCI in people with SCD and normal TCD velocities
Long‐term RBC transfusion showed no clear difference in clinical stroke compared with standard care (low certainty).
1 finding from 1 review
Cognitive function · prevention of SCI in people with SCD and normal TCD velocities
1 finding from 1 review
Quality of life · prevention of SCI in people with SCD and normal TCD velocities
1 finding from 1 review
Proportion of participants developing new or progressive SCI lesions · prevention of SCI in people with SCD and abnormal TCD velocities
Long‐term RBC transfusion may leads to lower proportion of participants developing new or progressive SCI lesions compared with standard care (low certainty).
1 finding from 1 review
All‐cause mortality · prevention of SCI in people with SCD and abnormal TCD velocities
1 finding from 1 review
Intervention not reported
SCD knowledge:children Pre‐ and post‐knowledge assessment Duration of · patients with sickle cell disease
1 finding from 1 review
Intervention not reported
Healthcare utilization clinic visits, emergency room visits and hospital admissions Duration of · patients with sickle cell disease
1 finding from 1 review
Intervention not reported
Positive coping Coping attempts and coping strategies Duration of · patients with sickle cell disease
1 finding from 1 review
Intervention not reported
Depression standardised depression scores · patients with sickle cell disease
1 finding from 1 review
Intervention not reported
Patient‐reported signs and symptoms/ self‐management · patients with sickle cell disease
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
SCD knowledge: caregiver Pre‐ and post‐knowledge assessment Duration of · caregivers of patients with sickle cell disease
1 finding from 1 review
Intervention not reported
Caregiver‐reported signs and symptoms Lead to self management · caregivers of patients with sickle cell disease
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found