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What do systematic reviews say?

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Evidence found and GRADE certainty

660 questions · 679 findings · 99 reviews · Headline outcomes only

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No studies found 160 · 23.6%GRADE not reported 17 · 2.5%Very low 199 · 29.3%Low 189 · 27.8%Moderate 97 · 14.3%High 17 · 2.5%

Summary of findings table ‐ Continuous infusion of intravenous loop diuretics vs bolus injection of intravenous loop diuretics

Mortality before hospital discharge · adults (aged greater than 18 years) with acute heart failure

Summary of findings table ‐ Continuous infusion of intravenous loop… showed no clear difference in all‐cause mortality (from admission to discharge) compared with bolus injection of intravenous loop diuretics (low certainty).

1 finding from 1 review

Summary of findings table ‐ Continuous infusion of intravenous loop diuretics vs bolus injection of intravenous loop diuretics

Hospital readmission · adults (aged greater than 18 years) with acute heart failure

Summary of findings table ‐ Continuous infusion of intravenous loop… showed no clear difference in readmission to hospital following discharge compared with bolus injection of intravenous loop diuretics (low certainty).

1 finding from 1 review

Summary of findings table ‐ Continuous infusion of intravenous loop diuretics vs bolus injection of intravenous loop diuretics

Acute kidney injury · adults (aged greater than 18 years) with acute heart failure

Summary of findings table ‐ Continuous infusion of intravenous loop… showed no clear difference in acute kidney injury (adverse event) (from admission to discharge) compared with bolus injection of intravenous loop diuretics (low certainty).

1 finding from 1 review

Repeated single embryo transfer (mixed policies) vs multiple embryo transfer

Cumulative live birth · transfer following in vitro fertilisation or intracytoplasmic sperm injection

Repeated single embryo transfer (mixed policies) showed no clear difference in cumulative live birth compared with multiple embryo transfer (low certainty).

1 finding from 1 review

Repeated single embryo transfer (mixed policies) vs multiple embryo transfer

Multiple pregnancy · transfer following in vitro fertilisation or intracytoplasmic sperm injection

Repeated single embryo transfer (mixed policies) probably leads to lower multiple pregnancy compared with multiple embryo transfer (moderate certainty).

1 finding from 1 review

Repeated single embryo transfer (mixed policies) vs multiple embryo transfer

Clinical pregnancy rate · transfer following in vitro fertilisation or intracytoplasmic sperm injection

Repeated single embryo transfer (mixed policies) showed no clear difference in clinical pregnancy rate compared with multiple embryo transfer (low certainty).

1 finding from 1 review

Repeated single embryo transfer (mixed policies) vs multiple embryo transfer

Miscarriage · transfer following in vitro fertilisation or intracytoplasmic sperm injection

Repeated single embryo transfer (mixed policies) showed no clear difference in miscarriage rate compared with multiple embryo transfer (low certainty).

1 finding from 1 review