The single stevia trial (Cocco 2019) reported a significant reduction in salivary Mutans streptococci and lactobacilli, but gave no effect size and was not GRADE-rated.
High‐dose chemotherapy showed no clear difference in overall survival at 5‐year compared with chemotherapy without bone marrow transplant or stem cell rescue (high certainty).
High‐dose chemotherapy showed no clear difference in event‐free survival at 5‐year compared with chemotherapy without bone marrow transplant or stem cell rescue (high certainty).
High‐dose chemotherapy leads to higher treatment‐related mortality compared with chemotherapy without bone marrow transplant or stem cell rescue (high certainty).
High‐dose chemotherapy showed no clear difference in second cancers at 4 ‐ 9‐year median compared with chemotherapy without bone marrow transplant or stem cell rescue (high certainty).
Pooled caries experience (DMFT) was similar in very-high-HDI and high-HDI countries, and meta-regression found no significant association between national HDI and DMFT; ungraded observational evidence with very high heterogeneity.
The review found no eligible studies for this question.
It is very uncertain whether high‐frequency oscillation changes mortality (at 30 days or until hospital discharge) compared with conventional ventilation (very low certainty).
It is very uncertain whether high‐frequency oscillation changes mortality (at 6 months) compared with conventional ventilation (very low certainty).
It is very uncertain whether high‐frequency oscillation changes treatment failure compared with conventional ventilation (very low certainty).
It is very uncertain whether high‐frequency oscillation changes barotrauma compared with conventional ventilation (very low certainty).
It is very uncertain whether high‐frequency oscillation changes hypotension compared with conventional ventilation (very low certainty).
High initial concentration showed no clear difference in cough compared with low initial concentration (low certainty).
High initial concentration showed no clear difference in laryngospasm compared with low initial concentration (low certainty).
High initial concentration showed no clear difference in breath holding compared with low initial concentration (low certainty).
High initial concentration may leads to higher apneoa compared with low initial concentration (low certainty).
High initial concentration showed no clear difference in patient movement compared with low initial concentration (low certainty).