Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

347 questions · 354 findings · 22 reviews

No studies found 100 · 28.2%GRADE not reported 37 · 10.5%Very low 115 · 32.5%Low 64 · 18.1%Moderate 23 · 6.5%High 15 · 4.2%

CLOZAPINE + ARIPIPRAZOLE vs CLOZAPINE + HALOPERIDOL (Cipriani 2013)

Acceptability of treatment ‐ leaving the study early · people with treatment‐resistant schizophrenia

It is very uncertain whether CLOZAPINE + ARIPIPRAZOLE changes leaving the study early: acceptability of treatment ‐ as measured by… compared with CLOZAPINE + HALOPERIDOL (Cipriani 2013) (very low certainty).

1 finding from 1 review

CLOZAPINE + ARIPIPRAZOLE vs CLOZAPINE + HALOPERIDOL (Cipriani 2013)

Quality of life/satisfaction with care for either recipients of care or carers: significant change in quality of life/satisfaction · people with treatment‐resistant schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Droperidol vs haloperidol

Adverse effects ‐ cardiovascular ‐ hypotension/desaturation · acute psychosis

Droperidol showed no clear difference in adverse effects ‐ cardiovascular ‐ hypotension/desaturation compared with haloperidol (low certainty).

1 finding from 1 review

Droperidol vs haloperidol

Mental state: mean score by 13 days (Scale for Quantification of Psychotic Symptom Severity, high = poor) · acute psychosis

Droperidol showed no clear difference in mental state: mean score by 13 days (Scale for Quantification of… compared with haloperidol (low certainty).

1 finding from 1 review

Droperidol vs haloperidol

Global state: use of additional medication ‐ by 60 minutes after initial adequate sedation until ED discharge (various psychotropic drugs) · acute psychosis

Droperidol leads to lower global state: use of additional medication ‐ by 60 minutes after… compared with haloperidol (high certainty).

1 finding from 1 review

CHLORPROMAZINE vs haloperidol

Global outcome: Number of additional injections ‐ 2‐4 injections · patients with psychosis‐induced aggression or agitation

It is very uncertain whether CHLORPROMAZINE changes global outcome: Number of additional injections ‐ 2‐4 injections compared with HALOPERIDOL (very low certainty).

1 finding from 1 review

CHLORPROMAZINE vs haloperidol

Global outcome: Number of additional injections ‐ 5 or more · patients with psychosis‐induced aggression or agitation

It is very uncertain whether CHLORPROMAZINE changes global outcome: Number of additional injections ‐ 5 or more compared with HALOPERIDOL (very low certainty).

1 finding from 1 review

CHLORPROMAZINE vs haloperidol

Adverse effects ‐ cardiovascular ‐ hypotension · patients with psychosis‐induced aggression or agitation

It is very uncertain whether CHLORPROMAZINE changes adverse effects ‐ cardiovascular ‐ hypotension compared with HALOPERIDOL (very low certainty).

1 finding from 1 review