Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,703 questions · 3,824 findings · 858 reviews

No studies found 573 · 15%GRADE not reported 383 · 10%Very low 993 · 26%Low 1,062 · 27.8%Moderate 614 · 16.1%High 199 · 5.2%

Low tooth brushing frequency (<2 times/day) vs High tooth brushing frequency (>=2 times/day)

Early childhood caries (ECC) · Healthy children under 6 years of age (6 months to 6 years); preschool children

After excluding an extreme outlier (Alhabdan 2018), the association between low brushing frequency and ECC remained statistically significant (pooled OR approximately 2.0, p=0.003; I2=87.5%); the exact estimate and its CI were not reported; ungraded.

2 findings from 1 review

Longer intervals (5‐15 days) (intervention) vs shorter intervals (2‐5 days) (control) between dressing changes

Catheter‐related blood stream infection · patients with a central venous catheter

Longer intervals (5‐15 days) (intervention) showed no clear difference in catheter‐related blood stream infection (CRBSI) compared with shorter intervals (2‐5 days) (control) between dressing changes (low certainty).

1 finding from 1 review

Longer intervals (5‐15 days) (intervention) vs shorter intervals (2‐5 days) (control) between dressing changes

All‐cause mortality · patients with a central venous catheter

Longer intervals (5‐15 days) (intervention) showed no clear difference in all‐cause mortality compared with shorter intervals (2‐5 days) (control) between dressing changes (low certainty).

1 finding from 1 review