Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

341 questions · 354 findings · 26 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

No studies found 58 · 16.4%GRADE not reported 4 · 1.1%Very low 51 · 14.4%Low 133 · 37.6%Moderate 82 · 23.2%High 26 · 7.3%

Intervention not reported

Death from all causes · patients with early stage cervical cancer

The intervention probably leads to lower death from all causes (moderate certainty).

1 finding from 1 review

Intervention not reported

Disease progression · patients with early stage cervical cancer

The intervention probably leads to lower disease progression (moderate certainty).

1 finding from 1 review

Intervention not reported

Grade 4 toxicity3 · patients with early stage cervical cancer

The intervention probably leads to higher grade 4 toxicity3 (moderate certainty).

1 finding from 1 review

Intervention not reported

Disease progression · patients with early stage cervical cancer

The intervention showed no clear difference in disease progression (low certainty).

1 finding from 1 review

Intervention not reported

Failure of first‐line therapy · women withe low‐risk GTN

The intervention probably leads to higher failure of first‐line therapy (moderate certainty).

1 finding from 1 review

Intervention not reported

Severe adverse events (≥ grade 3) · women withe low‐risk GTN

The intervention showed no clear difference in severe adverse events (≥ grade 3) (low certainty).

1 finding from 1 review

Intervention not reported

5‐ year OS · women with stage III or IV endometrial cancer after primary cytoreductive surgery

The intervention probably leads to lower 5‐ year OS (moderate certainty).

1 finding from 1 review

Intervention not reported

5‐year PFS · women with stage III or IV endometrial cancer after primary cytoreductive surgery

The intervention probably leads to lower 5‐year PFS (moderate certainty).

1 finding from 1 review

Intervention not reported

5‐year OS (stage III) · women with stage III or IV endometrial cancer after primary cytoreductive surgery

The intervention showed no clear difference in 5‐year OS (stage III) (moderate certainty).

1 finding from 1 review

Intervention not reported

5‐year PFS (stage III) · women with stage III or IV endometrial cancer after primary cytoreductive surgery

The intervention showed no clear difference in 5‐year PFS (stage III) (moderate certainty).

1 finding from 1 review