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Evidence found and GRADE certainty

4,756 questions · 11,779 findings · 747 reviews · Headline outcomes only

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No studies found 3,205 · 27.2%GRADE not reported 628 · 5.3%Very low 3,261 · 27.7%Low 2,913 · 24.7%Moderate 1,453 · 12.3%High 319 · 2.7%

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Arginine butyrate plus standard care alone vs usual care

Ulcer healing · individuals with sickle cell disease and a leg ulcer

It is very uncertain whether arginine butyrate plus standard care alone changes complete leg ulcer closure (defined as 100% epithelization or skin… compared with standard care alone (very low certainty).

1 finding from 1 review

Primary‐level worker‐led collaborative care vs usual care

CMD symptoms ‐ intermediate term (1 to 6 months post intervention) Measured by change in CIS‐Rg; GHQ‐12i; HDRSc; PHQ‐9e,j,k scores from baseline (greater decline = greater improvement) · adults with common mental disorders
1 finding from 1 review

Primary‐level worker‐led collaborative care vs usual care

Service utilisation ‐ referral to mental health team ‐ long term (7 to 12 months post intervention)Â · adults with common mental disorders

Primary‐level worker‐led collaborative care may leads to lower service utilisation ‐ referral to mental health team ‐ long term (7… compared with usual care (low certainty).

1 finding from 1 review

Primary‐level worker‐led collaborative care vs usual care

Adverse events ‐ death · adults with common mental disorders

It is very uncertain whether primary‐level worker‐led collaborative care changes adverse events ‐ death compared with usual care (very low certainty).

1 finding from 1 review

Lay health worker‐ vs specialist‐led care

Clinical recovery from severe mental disorder (immediately post intervention) Defined by BPRS decreased by ≥ 80% (RR > 1 denotes greater likelihood of recovery) · people with severe mental disorders

The review found no eligible studies for this question.

1 finding from 1 review

Primary‐level worker‐led collaborative care vs usual care

Recovery from CMD ‐ intermediate term (1 to 6 months post intervention) Recovery defined by GDS ≤ 11a; HDRS < 7b; HDRS < 8c; PHQ‐9 < 6d; PHQ‐9 < 5 or 50% reduction from baselinee (RR > 1 denotes greater likelihood of recovery) · adults with common mental disorders

Primary‐level worker‐led collaborative care may leads to higher recovery from CMD ‐ intermediate term (1 to 6 months post… compared with usual care (low certainty).

1 finding from 1 review

Lay health worker‐ vs specialist‐led care

Caregiver burden · people with severe mental disorders

Lay health worker‐ showed no clear difference in caregiver burden symptom severity ‐ immediately post intervention… compared with specialist‐led care (low certainty).

1 finding from 1 review