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Evidence found and GRADE certainty

4,730 questions · 18,059 findings · 1,282 reviews

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No studies found 4,360 · 24.1%GRADE not reported 2,529 · 14%Very low 4,641 · 25.7%Low 4,007 · 22.2%Moderate 2,057 · 11.4%High 465 · 2.6%

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PET-CT following chemoradiotherapy (neck dissection only if no/incomplete response) vs Planned neck dissection before or after chemoradiotherapy

Adverse events associated with treatment · Adults with oral cavity or oropharyngeal cancer with nodal disease (stage N2 or N3)
1 finding from 1 review

Light-emitting diode (LED) photobiomodulation vs Conventional orthodontic appliance treatment

Duration of orthodontic treatment: alignment stage (mandibular arch) · Adolescents and adults with malocclusion undergoing fixed orthodontic appliance treatment

It is very uncertain whether light-emitting diode (LED) photobiomodulation changes duration of orthodontic treatment: alignment stage (mandibular arch) compared with conventional orthodontic appliance treatment (very low certainty).

1 finding from 1 review

PET-CT following chemoradiotherapy (neck dissection only if no/incomplete response) vs Planned neck dissection before or after chemoradiotherapy

Disease-free survival · Adults with oral cavity or oropharyngeal cancer with nodal disease (stage N2 or N3)
1 finding from 1 review

Elective radical (comprehensive) neck dissection vs Elective selective neck dissection

Disease-free survival · Adults with oral cavity cancer

It is very uncertain whether elective radical (comprehensive) neck dissection changes disease-free survival (new disease, progression, and mortality) compared with elective selective neck dissection (very low certainty).

1 finding from 1 review

High-viscosity GIC atraumatic restorative treatment vs No control

Restoration survival · Children with decayed primary molar teeth

Multi-surface ART restorations had a reported survival rate of 73% at 1 year.

4 findings from 1 review
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Chlorhexidine gel (0.2%, intrasocket) vs placebo or no treatment

Adverse events · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)
1 finding from 1 review
  • Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
    Follow-up: median 7 days
    No adverse events were reported. Six trials (673 participants) reported no adverse events from the use of chlorhexidine gel; one study (Rubio-Palau 2015) reported gastrointestinal discomfort (30, 18%), dizziness (10,…
    7 studies
    GRADE not reported

Neocone vs Alvogyl

Time to initial pain relief (minutes) · Adults (>18 years) with established dry socket following permanent tooth extraction

Neocone led to higher time to initial pain relief (minutes) compared with alvogyl; GRADE not reported.

1 finding from 1 review

Tranexamic acid (AMCA cones) vs Placebo (lactose cones)

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Tranexamic acid (AMCA cones) showed no clear difference in presence of dry socket compared with placebo (lactose cones); GRADE not reported.

1 finding from 1 review

Primary closure of the extraction socket with a mucoperiosteal flap vs Application of platelet-rich fibrin (PRF) without primary closure

MRONJ (incidence proportion) · People on antiresorptive treatment undergoing tooth extraction (at risk of MRONJ)
1 finding from 1 review
  • Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes
    90 days
    All participants had complete mucosal coverage without any signs of MRONJ at the final control examination 90 days postoperatively (77 randomised; 1 RCT); no case of postoperative MRONJ in either group; effect not…
    1 study · 77 participants
    GRADE not reported

Stepwise excavation (two-stage caries removal, re-entry after an interval) vs Non-selective or complete carious tissue removal

Pulp exposure during caries removal · Children (3-11 years) with symptomless, vital dentine caries in primary molars

Stepwise excavation reduced the reported risk of pulp exposure by 69% versus complete caries removal (RR 0.31; ungraded).

1 finding from 1 review

Apernyl (acetylsalicylic acid pellet) vs placebo

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Apernyl (acetylsalicylic acid pellet) showed no clear difference in presence of dry socket compared with placebo; GRADE not reported.

1 finding from 1 review

Advanced platelet rich fibrin (A-PRF) vs No active treatment (control)

Pain (VAS cm) · Adults (>18 years) with established dry socket following permanent tooth extraction

Advanced platelet rich fibrin (A-PRF) led to lower pain (VAS cm) compared with control (no treatment); GRADE not reported.

1 finding from 1 review

SaliCept (acemannan hydrogel) vs no treatment

Pain (VAS) · Adults (>18 years) with established dry socket following permanent tooth extraction
1 finding from 1 review