Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,801 questions · 4,079 findings · 473 reviews

No studies found 669 · 16.4%GRADE not reported 852 · 20.9%Very low 738 · 18.1%Low 903 · 22.1%Moderate 716 · 17.6%High 201 · 4.9%

Intervention not reported

Pooled sensitivity 87% (75% to 93%) · children with close tuberculosis contacts Index test: abnormal chest radiography Role: an initial test Threshold for index tests: author…
1 finding from 1 review

Intervention not reported

Pooled specificity 99% (68% to 100%) · children with close tuberculosis contacts Index test: abnormal chest radiography Role: an initial test Threshold for index tests: author…
1 finding from 1 review

Intervention not reported

Estimations · children evaluated in inpatient or outpatient settings Index tests: Xpert MTB/RIF Role: an initial test Threshold for index tests: an…

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Sensitivities 43% and 100% · children evaluated in inpatient or outpatient settings Index tests: Xpert MTB/RIF Role: an initial test Threshold for index tests: an…
1 finding from 1 review

Retrievable vena caval filters with anticoagulation vs anticoagulation

Mortality (up to 6 months) · participants with unprovoked acute symptomatic PE and at high risk for recurrent PEa

Retrievable vena caval filters with anticoagulation showed no clear difference in mortality (up to 6 months) compared with anticoagulation (moderate certainty).

1 finding from 1 review

Retrievable vena caval filters with anticoagulation vs anticoagulation

Symtomatic lower extremity venous thrombosis confirmed by Doppler ultrasound or venography (up to 6 months) · participants with unprovoked acute symptomatic PE and at high risk for recurrent PEa

Retrievable vena caval filters with anticoagulation showed no clear difference in symtomatic lower extremity venous thrombosis confirmed by Doppler… compared with anticoagulation (moderate certainty).

1 finding from 1 review

Retrievable vena caval filters with anticoagulation vs anticoagulation

Major bleeding · participants with unprovoked acute symptomatic PE and at high risk for recurrent PEa

Retrievable vena caval filters with anticoagulation showed no clear difference in major bleedingc (up to 6 months) compared with anticoagulation (moderate certainty).

1 finding from 1 review

Summary of findings: monoclonal antibody KB001‐A vs placebo

Respiratory function number of episodes of a drop in FEV1 (unit of measurement not given) · children (12 or over) and adults with cystic fibrosis and lung infection

It is very uncertain whether summary of findings: monoclonal antibody KB001‐A changes respiratory function number of episodes of a drop in FEV1 (unit of… compared with placebo (very low certainty).

1 finding from 1 review

Summary of findings: monoclonal antibody KB001‐A vs placebo

Number experiencing adverse effects · children (12 or over) and adults with cystic fibrosis and lung infection

It is very uncertain whether summary of findings: monoclonal antibody KB001‐A changes adverse events number of participants experiencing adverse events compared with placebo (very low certainty).

1 finding from 1 review

Summary of findings: monoclonal antibody KB001‐A vs placebo

Need for antibiotics time to need for antibiotics · children (12 or over) and adults with cystic fibrosis and lung infection

Summary of findings: monoclonal antibody KB001‐A showed no clear difference in need for antibiotics time to need for antibiotics compared with placebo (moderate certainty).

1 finding from 1 review