Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,776 questions · 7,311 findings · 959 reviews · Headline outcomes only

No studies found 1,498 · 20.5%GRADE not reported 303 · 4.1%Very low 1,839 · 25.2%Low 1,991 · 27.2%Moderate 1,277 · 17.5%High 403 · 5.5%

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MDAC + hospital intervention vs SDAC + hospital intervention

Incidence of admissions to the ICU · first aid in patients with acute oral poisoning (carbamazepine, yellow oleander, or combinations of different drugs)

MDAC + hospital intervention may leads to lower incidence of ICU admission compared with SDAC + hospital intervention (low certainty).

1 finding from 1 review

MDAC + hospital intervention vs hospital intervention

Incidence of mortality · first aid in patients with acute oral poisoning (benzodiazepines, yellow oleander or combinations of different drugs)

MDAC + hospital intervention showed no clear difference in incidence of mortality compared with hospital intervention (low certainty).

1 finding from 1 review

MDAC + hospital intervention vs hospital intervention

Incidence of adverse events · first aid in patients with acute oral poisoning (benzodiazepines, yellow oleander or combinations of different drugs)

MDAC + hospital intervention showed no clear difference in incidence of adverse events compared with hospital intervention (low certainty).

1 finding from 1 review

MDAC + hospital intervention vs hospital intervention

Incidence and severity of symptoms of poisoning: incidence of need for intubation · first aid in patients with acute oral poisoning (benzodiazepines, yellow oleander or combinations of different drugs)

MDAC + hospital intervention showed no clear difference in incidence and severity of symptoms of poisoning: incidence of need… compared with hospital intervention (low certainty).

1 finding from 1 review

SDAC + hospital intervention vs hospital intervention

Incidence of mortality · first aid in patients with acute oral poisoning (not specified, tricyclic antidepressants, combinations of different drugs or yellow…

SDAC + hospital intervention showed no clear difference in incidence of mortality compared with hospital intervention alone (low certainty).

1 finding from 1 review

Repeated lumbar or ventricular punctures vs conservative treatment

Hydrocephalus shunt · preterm infants less than three months of age with either: a) IVH demonstrated by ultrasound or computed tomography (CT) scan; or b)…

Repeated lumbar or ventricular punctures showed no clear difference in hydrocephalus shunt compared with conservative treatment (moderate certainty).

1 finding from 1 review

Repeated lumbar or ventricular punctures vs conservative treatment

Death · preterm infants less than three months of age with either: a) IVH demonstrated by ultrasound or computed tomography (CT) scan; or b)…

Repeated lumbar or ventricular punctures showed no clear difference in death compared with conservative treatment (low certainty).

1 finding from 1 review

Repeated lumbar or ventricular punctures vs conservative treatment

Major disability in survivors · preterm infants less than three months of age with either: a) IVH demonstrated by ultrasound or computed tomography (CT) scan; or b)…

Repeated lumbar or ventricular punctures showed no clear difference in major disability in survivors compared with conservative treatment (high certainty).

1 finding from 1 review

Repeated lumbar or ventricular punctures vs conservative treatment

Multiple disability in survivors · preterm infants less than three months of age with either: a) IVH demonstrated by ultrasound or computed tomography (CT) scan; or b)…

Repeated lumbar or ventricular punctures showed no clear difference in multiple disability in survivors compared with conservative treatment (high certainty).

1 finding from 1 review

Repeated lumbar or ventricular punctures vs conservative treatment

Death or disability · preterm infants less than three months of age with either: a) IVH demonstrated by ultrasound or computed tomography (CT) scan; or b)…

Repeated lumbar or ventricular punctures showed no clear difference in death or disability compared with conservative treatment (high certainty).

1 finding from 1 review

Repeated lumbar or ventricular punctures vs conservative treatment

Death or shunt · preterm infants less than three months of age with either: a) IVH demonstrated by ultrasound or computed tomography (CT) scan; or b)…

Repeated lumbar or ventricular punctures showed no clear difference in death or shunt compared with conservative treatment (moderate certainty).

1 finding from 1 review

Repeated lumbar or ventricular punctures vs conservative treatment

Infection of CSF presurgery · preterm infants less than three months of age with either: a) IVH demonstrated by ultrasound or computed tomography (CT) scan; or b)…

Repeated lumbar or ventricular punctures showed no clear difference in infection of CSF presurgery compared with conservative treatment (low certainty).

1 finding from 1 review

Rapid vs slow taper of buprenorphine dose

Completion of withdrawal treatment − Outpatient · Adults or adolescents with opioid dependence

It is very uncertain whether rapid changes completion of withdrawal treatment − Outpatient compared with slow taper of buprenorphine dose (very low certainty).

1 finding from 1 review