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Evidence found and GRADE certainty

4,534 questions · 5,247 findings · 456 reviews

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No studies found 1,142 · 21.8%GRADE not reported 1,503 · 28.6%Very low 1,040 · 19.8%Low 869 · 16.6%Moderate 554 · 10.6%High 139 · 2.6%

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Bilateral extraction of compromised mandibular first permanent molars vs Age- and gender-matched non-extraction controls

Skeletal development (occlusal plane rotation, facial height) · Children (approximately 11 years or older) with compromised mandibular first permanent molars

Bilateral lower first permanent molar extraction was associated with counter-clockwise rotation of the occlusal plane and a mild decrease in lower anterior face height in one case-control study; ungraded.

1 finding from 1 review

Low income vs High income

Prevalence of fair/poor self-rated oral health · Adults aged 25 years and older in Australia, Canada, New Zealand, and the United States

Across four countries, low versus high income differed by 15.77 percentage points in prevalence of fair/poor self-rated oral health (random-effects meta-analysis; I2=13.4%).

5 findings from 1 review
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Primary education vs University education

Mean number of decayed teeth (mean DT) · Adults aged 25 years and older in Australia, Canada, New Zealand, and the United States

In Canada, primary versus university education differed by 0.69 decayed teeth in mean number of decayed teeth.

5 findings from 1 review
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Activator functional appliance vs Prefabricated functional myobrace appliance (PFA)

Final overjet · Adolescents (age 12 to 16 years) receiving orthodontic treatment to correct prominent upper front teeth (Class II malocclusion)

Activator functional appliance showed no clear difference in final overjet compared with prefabricated functional myobrace appliance (PFA); GRADE not reported.

1 finding from 1 review

Secondary education vs University education

Prevalence of untreated decay (% DT > 0) · Adults aged 25 years and older in Australia, Canada, New Zealand, and the United States

In United States, secondary versus university education differed by 10.4 percentage points in prevalence of untreated decay.

4 findings from 1 review
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R-appliance vs Anterior inclined bite plate (AIBP)

Final ANB · Adolescents (age 12 to 16 years) receiving orthodontic treatment to correct prominent upper front teeth (Class II malocclusion)

R-appliance showed no clear difference in final ANB compared with anterior inclined bite plate (AIBP); GRADE not reported.

1 finding from 1 review

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs Placebo mouthwash

Bleeding duration (minutes, all types of bleeding, minor and major) · People on continuous VKA treatment undergoing minor oral surgery or dental extractions (eligibility included DOACs and all ages; all four…

The review found no eligible studies for this question.

1 finding from 1 review

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs Placebo mouthwash

Adverse effects requiring withdrawal/discontinuation of study medication · People on continuous VKA treatment undergoing minor oral surgery or dental extractions (eligibility included DOACs and all ages; all four…

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA)… showed no clear difference in side effects or other adverse events requiring withdrawal compared with placebo (placebo solution/mouthwash) (moderate certainty).

1 finding from 1 review

Orthodontic treatment without extraction of permanent teeth vs Orthodontic treatment involving extraction of permanent teeth

Cephalometric measurements (ANB change and front teeth inclination changes) · Children (80% aged <= 16 years) with a Class II division 2 malocclusion (deep bite and retroclined upper front teeth)

The review found no eligible studies for this question.

1 finding from 1 review

Late treatment (one-phase) with removable functional appliance vs no treatment

Final ANB · Adolescents (age 12 to 16 years) receiving orthodontic treatment to correct prominent upper front teeth (Class II malocclusion)

Late treatment (one-phase) with removable functional appliance may leads to lower final ANB compared with no treatment (low certainty).

1 finding from 1 review

Late treatment (one-phase) with fixed functional appliance vs no treatment

Final ANB · Adolescents (age 12 to 16 years) receiving orthodontic treatment to correct prominent upper front teeth (Class II malocclusion)

Late treatment (one-phase) with fixed functional appliance showed no clear difference in final ANB compared with no treatment (low certainty).

1 finding from 1 review

Activator functional appliance vs Fixed functional appliance (FORSUS FRD EZ)

Final ANB · Adolescents (age 12 to 16 years) receiving orthodontic treatment to correct prominent upper front teeth (Class II malocclusion)

Activator functional appliance led to lower final ANB compared with fixed functional appliance (FORSUS FRD EZ); GRADE not reported.

1 finding from 1 review

Removable functional appliance vs Fixed functional appliance

Final ANB · Adolescents (age 12 to 16 years) receiving orthodontic treatment to correct prominent upper front teeth (Class II malocclusion)

Removable functional appliance may leads to lower final ANB compared with fixed functional appliance (low certainty).

1 finding from 1 review

Passive tobacco exposure (prenatal maternal smoking or postnatal secondhand/household smoke) vs No passive tobacco exposure (non-exposed children)

Dental caries · Children and adolescents (general population, aged under 20 years)

In children and adolescents, passive tobacco exposure (prenatal or postnatal) is associated with higher odds of dental caries (pooled OR 1.53, 95% CI 1.39 to 1.68; 21 studies), though heterogeneity was high (I2=86.5%); certainty of evidence not graded.

1 finding from 1 review

Harvold Activator vs Frankel function regulator

Occlusion (net change in overjet, short term) · Adolescents (age 12 to 16 years) receiving orthodontic treatment to correct prominent upper front teeth (Class II malocclusion)

Harvold Activator led to lower overjet change compared with frankel function regulator; GRADE not reported.

1 finding from 1 review

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs Placebo mouthwash

Change in haemoglobin level from baseline · People on continuous VKA treatment undergoing minor oral surgery or dental extractions (eligibility included DOACs and all ages; all four…

The review found no eligible studies for this question.

1 finding from 1 review