Findings

What do systematic reviews say?

3,234 questions · 3,357 findings · 396 reviews

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No studies found 803 · 23.9%GRADE not reported 270 · 8%Very low 757 · 22.5%Low 859 · 25.6%Moderate 486 · 14.5%High 182 · 5.4%

Intervention not reported

At least one AE · adults with migraine headache ‐ moderate or severe pain

1 finding from 1 review

Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Intervention not reported

Sustained pain‐free at 24 h · adults with migraine headache ‐ moderate or severe pain

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Sustained headache relief at 24 h · adults with migraine headache ‐ moderate or severe pain

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Serious AE · adults with migraine headache ‐ moderate or severe pain

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Combined paracetamol plus ibuprofen in a single tablet (e.g. paracetamol 1000 mg/ibuprofen 400 mg or 500/200 mg) vs Single drugs given separately (paracetamol 1000 mg or ibuprofen 400 mg)

Patients not using rescue medication at 8 hours · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…

Combined paracetamol plus ibuprofen in a single tablet (e.g.… leads to higher patients not using rescue medication at 8 hours compared with single drugs given separately (paracetamol 1000 mg or ibuprofen 400… (high certainty).

1 finding from 1 review

Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes
8 hours postdosing · Paracetamol 1000/500 mg/ibuprofen 400/200 mg vs single constituent drugs
RR 1.60 [1.36, 1.88]
2 studies · 467 participants
High

Rectal 5‐ASA vs placebo

Symptomatic remission · Patients with quiescent ulcerative colitis

Rectal 5‐ASA may leads to higher symptomatic remission compared with placebo (low certainty).

1 finding from 1 review

Rectal 5‐aminosalicylic acid for maintenance of remission in ulcerative colitis 2012 · Cochrane Headline outcomes only
RR 2.22 [1.26, 3.9]
4 studies · 301 participants
Low

Rectal 5‐ASA vs oral 5‐ASA

Symptomatic remission · Patients with quiescent ulcerative colitis

Rectal 5‐ASA showed no clear difference in symptomatic remission compared with oral 5‐ASA (low certainty).

1 finding from 1 review

Rectal 5‐aminosalicylic acid for maintenance of remission in ulcerative colitis 2012 · Cochrane Headline outcomes only
RR 1.24 [0.92, 1.66]
2 studies · 69 participants
Low

Rectal 5‐ASA vs oral 5‐ASA

Endoscopic remission · Patients with quiescent ulcerative colitis

Rectal 5‐ASA showed no clear difference in endoscopic remission compared with oral 5‐ASA (low certainty).

1 finding from 1 review

Rectal 5‐aminosalicylic acid for maintenance of remission in ulcerative colitis 2012 · Cochrane Headline outcomes only
RR 1.14 [0.9, 1.45]
2 studies · 91 participants
Low

Intervention not reported

Pulmonary Methotrexate pneumonitis · patients with inflammatory arthritis on methotrexate

1 finding from 1 review

Safety of non‐steroidal anti‐inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving… 2011 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 27 participants
Moderate

Intervention not reported

Hepatic Liver histology/hepatic enzyme abnormalities2 · patients with inflammatory arthritis on methotrexate

1 finding from 1 review

Safety of non‐steroidal anti‐inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving… 2011 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 272 participants
Low

Intervention not reported

Renal Glomerular and tubular injury · patients with inflammatory arthritis on methotrexate

1 finding from 1 review

Safety of non‐steroidal anti‐inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving… 2011 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 30 participants
Low

Intervention not reported

Haematological Thrombocytopenia · patients with inflammatory arthritis on methotrexate

1 finding from 1 review

Safety of non‐steroidal anti‐inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving… 2011 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 1 participants
Moderate

Intervention not reported

Withdrawal due to adverse events Methotrexate discontinuation · patients with inflammatory arthritis on methotrexate

1 finding from 1 review

Safety of non‐steroidal anti‐inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving… 2011 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 632 participants
Low

Intervention not reported

All adverse events · patients with inflammatory arthritis on methotrexate

1 finding from 1 review

Safety of non‐steroidal anti‐inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving… 2011 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 283 participants
Moderate