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Evidence found and GRADE certainty

3,288 questions · 3,354 findings · 516 reviews · Headline outcomes only

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No studies found 720 · 21.5%GRADE not reported 164 · 4.9%Very low 950 · 28.3%Low 932 · 27.8%Moderate 434 · 12.9%High 154 · 4.6%

Benzbromarone vs allopurinol

Serum urate normalisation ‐ not reported · people with chronic gout

Benzbromarone showed no clear difference in serum urate normalisation compared with allopurinol (moderate certainty).

1 finding from 1 review

Benzbromarone vs allopurinol

Withdrawals due to adverse events · people with chronic gout

Benzbromarone showed no clear difference in withdrawal due to adverse events compared with allopurinol (low certainty).

1 finding from 1 review

Benzbromarone vs probenecid

Acute gout attacks · people with chronic gout

Benzbromarone showed no clear difference in acute gout attacks compared with probenecid (low certainty).

1 finding from 1 review

Benzbromarone vs probenecid

Serum urate normalisation ≤ 5 mg/dL (≤ 0.3 mmol/L) · people with chronic gout

Benzbromarone probably leads to higher serum urate normalisation ≤ 5 mg/dL (≤ 0.3 mmol/L) compared with probenecid (moderate certainty).

1 finding from 1 review

Proton pump inhibitors (PPI) vs control

Number of participants with worsening scores in corporal atrophy · people with pre‐malignant lesions

Proton pump inhibitor showed no clear difference in number of participants with worsening scores in corporal atrophy compared with control (low certainty).

1 finding from 1 review

Proton pump inhibitors (PPI) vs control

Number of participants with worsening scores in corporal intestinal metaplasia · people with pre‐malignant lesions

Proton pump inhibitor showed no clear difference in number of participants with worsening scores in corporal intestinal… compared with control (low certainty).

1 finding from 1 review

Proton pump inhibitors (PPI) vs control

Increase in the number of participants with simple (diffuse) hyperplasia after treatment · people with pre‐malignant lesions

It is very uncertain whether proton pump inhibitor changes increase in the number of participants with simple (diffuse)… compared with control (very low certainty).

1 finding from 1 review

Proton pump inhibitors (PPI) vs control

Increase in the number of participants with linear/micronodular (focal) hyperplasia, comparing final biopsies with baseline biopsies · people with pre‐malignant lesions

Proton pump inhibitor may leads to higher increase in the number of participants with linear/micronodular… compared with control (low certainty).

1 finding from 1 review

Intervention not reported

months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers)

The intervention probably leads to lower months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐… (moderate certainty).

1 finding from 1 review

Intervention not reported

Symptom relief at 72 hours Patient reported

The intervention may leads to higher symptom relief at 72 hours Patient reported (low certainty).

1 finding from 1 review

Intervention not reported

Total adverse effects Patient reported

The intervention showed no clear difference in total adverse effects Patient reported (low certainty).

1 finding from 1 review

Intervention not reported

Adverse effects necessitating stop of therapy Patient reported

The intervention probably leads to higher adverse effects necessitating stop of therapy Patient reported (moderate certainty).

1 finding from 1 review