Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,231 questions · 3,354 findings · 394 reviews

No studies found 803 · 23.9%GRADE not reported 267 · 8%Very low 757 · 22.6%Low 859 · 25.6%Moderate 486 · 14.5%High 182 · 5.4%

Intervention not reported

Patient‐reported disease‐specific symptom scores Symptom score with scale of 0 to 3 (0 = no symptoms, 3 = severe symptoms)

The intervention showed no clear difference in patient‐reported disease‐specific symptom scores Symptom score with… (low certainty).

1 finding from 1 review

Intervention not reported

Health‐related quality of life scores, measured by SF‐36 (range 0 to 100)

The intervention showed no clear difference in health‐related quality of life scores, measured by SF‐36 (range 0 to… (low certainty).

1 finding from 1 review

Intervention not reported

Endoscopic appearances 0 to 3 (0 = no polyps, 3 = severe polyposis)

The intervention showed no clear difference in endoscopic appearances 0 to 3 (0 = no polyps, 3 = severe polyposis) (low certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality or liver‐related morbidity · patients with chronic hepatitis C

It is very uncertain whether the intervention changes all‐cause mortality or liver‐related morbidity (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events · patients with chronic hepatitis C

The intervention showed no clear difference in adverse events (moderate certainty).

1 finding from 1 review

Intervention not reported

Failure of end of treatment virological response Absence of clearance of HCV RNA from the blood at end of treatment · patients with chronic hepatitis C

The intervention showed no clear difference in failure of end of treatment virological response Absence of… (moderate certainty).

1 finding from 1 review

Intervention not reported

Failure of sustained virological response Absence of clearance of HCV RNA from the blood 6 months after treatment · patients with chronic hepatitis C

The intervention showed no clear difference in failure of sustained virological response Absence of clearance of… (moderate certainty).

1 finding from 1 review

Intervention not reported

Quality of life Different QoL scales · patients with chronic hepatitis C
1 finding from 1 review

Intervention not reported

Failure of normalisation of ALT at end of treatment · patients with chronic hepatitis C

The intervention may leads to lower failure of normalisation of ALT at end of treatment (low certainty).

1 finding from 1 review

Intervention not reported

Failure of normalisation of ALT at end of · patients with chronic hepatitis C

The intervention showed no clear difference in failure of normalisation of ALT at end of (low certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality or liver‐related morbidity · patients with chronic hepatitis C.

It is very uncertain whether the intervention changes all‐cause mortality or liver‐related morbidity (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events · patients with chronic hepatitis C.

It is very uncertain whether the intervention changes adverse events (very low certainty).

1 finding from 1 review

Intervention not reported

Failure of sustained virological response Absence of clearance of HCV RNA from the blood 6 months after treatment · patients with chronic hepatitis C.

The intervention may leads to higher failure of sustained virological response Absence of clearance of… (low certainty).

1 finding from 1 review

Intervention not reported

Failure of end of treatment virological response Absence of clearance of HCV RNA from the blood at end of treatment · patients with chronic hepatitis C.

The intervention may leads to higher failure of end of treatment virological response Absence of… (low certainty).

1 finding from 1 review

Intervention not reported

Failure of normalisation of ALT at end of treatment · patients with chronic hepatitis C.

It is very uncertain whether the intervention changes failure of normalisation of ALT at end of treatment (very low certainty).

1 finding from 1 review

Intervention not reported

Failure of normalisation of ALT at end of · patients with chronic hepatitis C.

It is very uncertain whether the intervention changes failure of normalisation of ALT at end of (very low certainty).

1 finding from 1 review

Combined paracetamol plus ibuprofen in a single tablet (e.g. paracetamol 1000 mg/ibuprofen 400 mg or 500/200 mg) vs Single drugs given separately (paracetamol 1000 mg or ibuprofen 400 mg)

Proportion of patients with >50% maximum pain relief (TOTPAR) over 2 hours · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…

Combined paracetamol plus ibuprofen in a single tablet (e.g.… showed no clear difference in proportion of patients with >50% maximum pain relief (TOTPAR) over 2… compared with single drugs given separately (paracetamol 1000 mg or ibuprofen 400… (moderate certainty).

1 finding from 1 review