Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

370 questions · 394 findings · 64 reviews

No studies found 88 · 22.3%GRADE not reported 20 · 5.1%Very low 74 · 18.8%Low 115 · 29.2%Moderate 87 · 22.1%High 10 · 2.5%

Inhaled steroids vs systemic steroids

General conceptual ability (GCA) score at 7 years The test has a standardisation mean of 100 and SD of 15 · Neonates with developing BPD

Inhaled steroids showed no clear difference in general conceptual ability (GCA) score at 7 years The test has a… compared with systemic steroids (moderate certainty).

1 finding from 1 review

Inhaled steroids vs systemic steroids

Systolic blood pressure > 95th percentile at 7 years · Neonates with developing BPD

Inhaled steroids showed no clear difference in systolic blood pressure > 95th percentile at 7 years compared with systemic steroids (moderate certainty).

1 finding from 1 review

Inhaled steroids vs systemic corticosteroids

BPD or death at 36 weeks' postmenstrual age№ of participants: 0 (0 RCTs) · preterm infants with respiratory distress for initial respiratory support

Inhaled steroids showed no clear difference in death or BPD at 36 weeks' postmenstrual age among all randomised compared with systemic corticosteroids (moderate certainty).

1 finding from 1 review

Inhaled steroids vs systemic corticosteroids

Death or BPD (28 days) · preterm infants with respiratory distress for initial respiratory support

Inhaled steroids showed no clear difference in death or BPD at 28 days compared with systemic corticosteroids (low certainty).

1 finding from 1 review

Inhaled steroids vs systemic corticosteroids

Bronchopulmonary dysplasia/chronic lung disease · preterm infants with respiratory distress for initial respiratory support

Inhaled steroids showed no clear difference in BPD at 36 weeks' postmenstrual age compared with systemic corticosteroids (moderate certainty).

1 finding from 1 review

Intervention not reported

Functional exercise capacity Multiple different outcome measures used SF‐36 PF and AT (at 9 and 26 weeks) (Batterham 2014) SF‐36 PF and 6MWT (at 8 and 26 weeks) (Elliott 2011) ABC, Katz, TUAG (at 3 months) (Jackson 2012) SF‐36 PCS ( · adult survivors of critical illness
1 finding from 1 review